Efficacy of Mirtazapine on Irritable Bowel Syndrome with Anxiety and Depression: A Case Study

Fumiaki Akama; Katsunaka Mikami; Natsuru Watanabe; Keitaro Kimoto; Kenji Yamamoto; Hideo Matsumoto

doi:10.1272/jnms.JNMS.2018_85-53

Case Reports

Efficacy of Mirtazapine on Irritable Bowel Syndrome with Anxiety and Depression: A Case Study

Fumiaki Akama, Katsunaka Mikami, Natsuru Watanabe, Keitaro Kimoto, Kenji Yamamoto, Hideo Matsumoto

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Keywords: irritable bowel syndrome, antidepressant, depression, anxiety, diarrhea, gut-brain axis

JOURNAL FREE ACCESS

2018 Volume 85 Issue 6 Pages 330-333

DOI https://doi.org/10.1272/jnms.JNMS.2018_85-53

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Abstract

Irritable bowel syndrome (IBS) is a disease in which gastrointestinal symptoms-primarily abdominal pain or discomfort and abnormal bowel movements persist chronically. For patients with IBS, mental illness, especially depression and/or anxiety, leads to a further lower quality of life. The purpose of this case study was to investigate the effects of mirtazapine (MIR) on mental health and IBS symptoms in a case of IBS accompanied by anxiety and a depressive state. This case report suggests that MIR is efficacious for the treatment of IBS with predominant diarrhea accompanied by depression and anxiety.

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