Receptor Specificity of Influenza A Viruses from Sea Mammals Correlates with Lung Sialyloligosaccharides in These Animals

Toshihiro Ito; Yoshihiro Kawaoka; Akiyo Nomura; Koichi Otsuki

doi:10.1292/jvms.61.955

Abstract

The distribution of specific receptors on target organs is a major factor in the host range restriction of influenza A viruses. To assess the correlation between host receptors and the receptor specificity of influenza A viruses from sea mammals, we examined the receptors for influenza A virus in seal and whale lungs. A binding assay using two sialyloligosaccharide (SAα2, 3Gal and SAα2, 6Gal)-specific lectins showed that SAα2, 3Gal, but not SAα2, 6Gal, was found in both seal and whale lungs. Correspondingly, seal and whale influenza viruses preferentially recognized SAα2, 3Gal, but not SAα2, 6Gal. These results indicate that sialyloligosaccharides present at the replication site of influenza A viruses correlate with the receptor recognition of the viruses isolated from sea mammals.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 改変禁止 4.0 国際]ライセンスの下に提供されています。
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja

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