Clinical Pediatric Endocrinology
Online ISSN : 1347-7358
Print ISSN : 0918-5739
ISSN-L : 0918-5739
Original Articles
Frequencies of spontaneous breast development and spontaneous menarche in Turner syndrome in Japan
Toshiaki TanakaYutaka IgarashiKeiichi OzonoKenji OhyamaMasamichi OgawaHisao OsadaKazumichi OnigataSusumu KanzakiHitoshi KohnoYoshiki SeinoHiroaki TakahashiToshihiro TajimaKatsuhiko TachibanaHiroyuki TanakaYoshikazu NishiTomonobu HasegawaKeinosuke FujitaTohru YorifujiReiko HorikawaSusumu Yokoya
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JOURNAL OPEN ACCESS

2015 Volume 24 Issue 4 Pages 167-173

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Abstract

The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

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© 2015 by The Japanese Society for Pediatric Endocrinology

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
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