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Chinese Journal of Virology. 2013, (01) Core

Virological Characterization of Influenza B Virus in China’s mainland during 2011～2012Chinese Full Text

HUANG Wei-juan,TAN Min-ju,LAN Yu,CHENG Yan-hui,WANG Zhao, LI Xi-yan,GUO Jun-feng,WEI He-jiang,CHEN Yao-yao,XIAO Ning,LIU Bin,SUI Hong-tao, ZHAO Xiang,WANG Da-yan,SHU Yue-long(Chinese National Influenza Center,National Institute for Viral Disease Control and Prevention,China CDC; WHO Collaborating Center for Reference and Research on Influenza,Beijing 102206,China)

Abstract: In order to understand the prevalence and variation of influenza B viruses,the antigenic and genetic characteristics of influenza B viruses circulating in China’s mainland during April,2011 to March,2012 were analyzed.The results showed the B Victoria lineage viruses were much more prevalent than B Yamagata lineage during this period,phylogenetic analysis showed vast majority of Victoria lineage viruses belong to genetic group 1,intra-clade reassortant between HA1 and NA gene was identified in a minor proportion of the viruses.72.8% of the B/Victoria-lineage viruses were antigenically closely related to the vaccine strain B/Brisbane/60/2008.B Yamagata component was not included in the trivalent influenza vaccine in China during the study period,however vast majority of B Yamagata lineage viruses were antigenically and genetically closely related to the representative virus B/Hubei-Wujiagang/158/2009（97.8%） and B/Sichuan-Anyue/139/2011（85.2%） in China,reassortant between HA1 and NA was not identified in B Yamagata lineage viruses.Overall,the predominant circulating influenza B viruses in 2011-2012 season in China were matched by current influenza vaccine and the selected representative viruses were proved to represent the antigenic and genetic characteristics of the circulating viruses.
Keywords：

Influenza B virus; Antigenic analysis; Genetic characteristics analysis;

  • DOI：

    10.13242/j.cnki.bingduxuebao.002349

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  • Subject：

  • Classification Code：

    R511.7

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