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A High Speed Detection Platform Based on Surface-Enhanced Raman Scattering for Monitoring Antibiotic-Induced Chemical Changes in Bacteria Cell Wall

Figure 5

SERS-based microbial diagnostics of a single bacterium.

(A) A single S. aureus resolved under light microscopy (arrow, inset) was subjected to SERS detection every 10 min for 90 min (various colored traces); the standard deviation among all recordings along the spectrum are shown in red. (B) Sequential SERS spectral evolution of a single live bacterium of S. aureus on exposure to vancomycin, which is known to actively disrupted bacterial cell wall.

Figure 5

doi: https://doi.org/10.1371/journal.pone.0005470.g005