A High Speed Detection Platform Based on Surface-Enhanced Raman Scattering for Monitoring Antibiotic-Induced Chemical Changes in Bacteria Cell Wall
Figure 5
SERS-based microbial diagnostics of a single bacterium.
(A) A single S. aureus resolved under light microscopy (arrow, inset) was subjected to SERS detection every 10 min for 90 min (various colored traces); the standard deviation among all recordings along the spectrum are shown in red. (B) Sequential SERS spectral evolution of a single live bacterium of S. aureus on exposure to vancomycin, which is known to actively disrupted bacterial cell wall.