Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer’s Pathology
Figure 8
Astrocytosis and microglial activation were observed in Tg4510 mice.
Micrograph representation (5X) of hippocampi stained for GFAP positive astrocytes (panels A-G) or Iba-1 positive microglia (panels H-N) in Ntg (A, D, H, K), APP+PS1 (B, E, I, L) and Tg4510 (C, F, J, M) mice kept on either NIH-31 (A, B, C, H, I, J) or KD diets (D, E, F, K, L, M). (G, N) Immunostaining was digitally quantified by Mirax image analysis. Data are presented as mean ± SEM. Scale bar = 500μm; inset scale bar = 100 μm ***p<0.0001.