Introduction

In China, hypertension is the second most common disease risk factor [1]. Approximately 177 million people are estimated to be living with hypertension, with relatively low rates of awareness and control of this condition. [2,3] Previous studies have shown that public health services may be making little contribution in informing patients of their hypertensive status, [4] and more research is needed to understand how the response to this disease can be improved in the context of a rapidly changing health system and an aging population. Also, although some research on hypertension management in China has been conducted, the direct associations of health insurance on hypertension management still remain unknown.

China’s health insurance coverage has increased rapidly from 45% in 2006 to around 90% in 2009, [5] but the effectiveness of health insurance packages for hypertensive patients is not yet well understood at the population level, even though some contain special measures for severely hypertensive patients. [6] Given China’s rapid development over the past decade and the changes in health insurance coverage over the last five years, it is essential to evaluate the impact of health insurance on hypertension management and control.

In this article we had three main objectives:

• Estimating the prevalence of hypertension in China during the period of the CHNS;
• Estimating the proportion of those with prevalent hypertension who were aware of their disease, receiving treatment for it, or had controlled blood pressure;
• Estimating the effect of increased health insurance coverage on the management of hypertension.

Method

Results

Demographic characteristics of the sample

A total of 25,936 new subjects were involved in the CHNS until 2009. From these 1609 (6.2%) new participants in wave 1989 and 14,356 (55.4%) subjects aged under 35 or with no age information were removed. Finally, a total of 9971 (38.4%) subjects were used in our study with a mean age of 52.5 (range 35.0 to 96.5 years old). Table 1 shows the descriptive statistics of the study sample. The health insurance coverage rate in this sample was 37.4%, and 45.5% of the total sample came from the 1991 wave.

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Table 1. Demographic and socio-economic properties of the sample.

https://doi.org/10.1371/journal.pone.0152091.t001

Prevalence of hypertension

Table 2 shows prevalence of hypertension along with multi-level logistic regression analysis results. Prevalence of hypertension among the whole sample was 28.3% (95% CI 27.3–29.2%) and increased to 31.5% (28.5–34.7%) in 2009. Trends in prevalence of hypertension were unchanged after standardization using the WHO Standard Population as a reference distribution. Age was significantly positively associated with prevalence of hypertension, and more than half of elderly individuals (over 65 years old) had hypertension. Consistent with previous studies, women had lower prevalence of hypertension than men with odds ratio 0.67 (95% CI 0.57–0.79). Obesity increased the odds ratio of being hypertensive by a factor of 4.48 (3.41–5.89). Heavy drinking was also positively associated with prevalence of hypertension with an odds ratio of 1.34 (1.11–1.61). However, smoking and income had little effect. Compared to Liaoning province, Jiangsu, Hubei, and Guangxi provinces had lower prevalence of hypertension.

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Table 2. Prevalence of hypertension by key risk factors.

https://doi.org/10.1371/journal.pone.0152091.t002

Trends in factors associated with hypertension

Fig 1 shows how trends in tobacco and alcohol use, BMI and health insurance coverage have changed over time in this survey. The smoking rate increased from 1991 to 1993, and gradually decreased after that. The obesity rate (including obesity and overweight) increased slightly from 1991 to 2009. Health insurance coverage increased over time and grew rapidly after 2006. In 2009, health insurance coverage reached around 90% in this sample.

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Fig 1. Trends in smoking, heavy drinking, obesity (including overweight and obesity) and health insurance coverage.

https://doi.org/10.1371/journal.pone.0152091.g001

Management and control of hypertension

Table 3 shows hypertension prevalence, awareness rates amongst hypertensives, treatment rates amongst diagnosed hypertensives, and control rates amongst medically-treated hypertensives in each wave. Fig 2 shows the trends in prevalence and outcomes of hypertension management over time. The proportion of people with hypertension who were aware of their condition gradually increased over time and reached 51.1% (95% CI 45.1–57.0%) in 2009 (Table 3). Table 4 shows the logistic regression results of management outcomes. Elderly, obese and well-educated subjects were more likely to be aware of their hypertension. Current smokers or people living in rural areas were less likely to know about their hypertension. Inequality in hypertension awareness rates was found among different provinces, with people from Jiangsu, Hubei, and Guangxi provinces more likely to be diagnosed (Table 4).

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Table 3. Prevalence, awareness, treatment and control of hypertension.

https://doi.org/10.1371/journal.pone.0152091.t003

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Table 4. Characteristics of management outcomes.

https://doi.org/10.1371/journal.pone.0152091.t004

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Fig 2. Trends in prevalence, awareness, treatment and control of hypertension.

https://doi.org/10.1371/journal.pone.0152091.g002

Among individuals who were diagnosed as hypertensive, treatment rates have increased rapidly from 66.2% (60.3–71.7%) to 89.7% (83.6–94.1%) over the 19 years (Table 3). Although treatment rates increased rapidly over time, only 32.1% (95% CI 24.2–40.8%) of treated people had their hypertension under control in the latest survey in 2009 (Table 3). Table 4 shows that only age and district were significantly associated with control, with older people or residents of Liaoning and Shandong provinces less likely to have their hypertension under control. There was no significant time trend in control rates amongst treated patients, and increased health insurance coverage also had little association with control.

Discussion

This is the first population-based study to assess trends in the management and control of hypertension using a household survey covering 19 years of rapid change in China, which used a similar sampling and data collection method for seven consecutive waves. Trends in prevalence and management of hypertension were comparable in each wave, along with their risk factors, so the results are comparable over time and enable comparison of the periods before and after coverage of insurance increased. This is also the first study to estimate the treatment effects of health insurance on prevalence and management of hypertension in China using propensity score matching.

Prevalence of hypertension reached about 30% after 1997, which is slightly higher than found in a cross-sectional study by Gao and colleagues in 2013 based on data collected from the 2007–2008 China National Diabetes and Metabolic Disorders Study. [10] This may be because of different definitions of hypertension in these two studies. Our method of defining hypertension was slightly less restrictive than that of Gao and colleagues, and may give increased prevalence estimates relative to their findings.

According to the latest Chinese guidelines for the management of hypertension, the prevalence of hypertension has significantly increased over time. [3] However, in this study, the time trend remains stable, which may be explained in two ways. First, the data used in the 2010 Chinese guidelines came from four surveys, with different study populations, methods and definitions. Second, we only used new participants in the CHNS, who have a similar age structure in each wave. Since age is the most important determinant of prevalence, similar age structures may result in a non-significant time trend while in other surveys, the age structure is changing in the study sample along with the aging process nationwide.

Consistent with previous studies, elderly men were at higher risk of hypertension, and obesity and heavy drinking had a strong positive effect on prevalence of hypertension. [4] People with middle incomes were more likely to have hypertension, which may be attributed to their lifestyles. The CHNS study does not include comprehensive information on salt intake, but according to previous studies, salt is widely used in home cooking in China. [11] Daily salt intake is generally higher in northern areas, and more than 80% of residents take salt in excess of dietary recommendations. [12] Unobserved differences in salt intake may explain regional or wealth-based differences in hypertension in this study. Smoking rates slightly decreased over time in this study, consistent with previous national surveys. [13] Also, consistent with previous studies, the prevalence of overweight and obesity in our study increased rapidly with rapid development in the economy and living standards in China. [14]

The awareness rate increased over time, and in the 2009 wave half of people who had hypertension were diagnosed. Although elderly and overweight people had greater awareness of their hypertensive status, the rate of awareness among these groups is still low given their much higher risk of hypertension. People living in rural areas and with lower education levels are less likely to be aware of their hypertension. This may be because these people lack the resources to obtain hypertension knowledge. Health education programs for elderly and rural populations may be effective ways to promote awareness of hypertension. [15] Differences in hypertension awareness between rural and urban areas may also relate to different types of health insurance targeting different populations. For instance, the New Rural Cooperative Medical Scheme (NCMS) covers people in rural areas while the Urban Resident/Employee Basic Medical Insurance covers people in urban areas. Our results indicate that there might be some inequity between urban and rural health insurance packages in early diagnoses of hypertension. Inequities in service utilization and health outcomes between urban and rural areas have been reported, especially in 1990s. [16]

Treatment rates amongst those diagnosed with hypertension increased to around 90% by 2009. However, among people receiving medication, the proportion of people who have actually achieved control of their hypertension was only 30%. This situation of low control of hypertension is consistent with previous studies both in China and other countries, which found limited hypertension-related knowledge, ignorance of non-pharmacological treatments, unsatisfactory medication adherence, and inappropriate medical treatment all limited the effectiveness of treatments. [3,17,18]

Although elderly people were at higher risk of hypertension, they were less likely to have controlled hypertension. This may be because systolic hypertension due to age-related factors such as arteriosclerosis was common among elderly people. [19] Previous studies have shown that it is more difficult to control systolic blood pressure than diastolic blood pressure, and combinations of two or more antihypertension drugs are required for effective treatment. [20] Also, inequalities in hypertension prevalence and management were found across provinces, which may be due to variation in lifestyles, dietary habits, health treatment costs, insurance reimbursement levels, and health promotion programs between different areas. However, there was not enough information about health policies and programs implemented at the sub-national levels, and more information and surveys are needed to explain this variation. Since prevention and management of hypertension are national health promotion goals, the inequalities across provinces indicate that stronger national-level monitoring and guidelines may be necessary to achieve national goals for hypertension control programs and policies.

Although increased health insurance coverage was significantly associated with increased levels of treatment, we found little effect of health insurance on control of hypertension. Some longitudinal studies in the US have shown a positive effect of health insurance on awareness and control of hypertension as well as drug adherence. [21] At the individual level, better health knowledge has been shown to be effective in promoting medication adherence and blood pressure control. [22] These findings indicate that there may be problems with the quality of treatment being received, access to drugs or adherence to management guidelines, together with personal health-seeking behavioral factors in China.

Hypertension, like other chronic diseases, needs long periods of outpatient treatment. However, some studies show that current Chinese medical benefit packages are still limited and mainly focus on inpatient costs. [23] A study in some provinces in China found that outpatient care for people with chronic diseases had very low reimbursement levels which indicates that people living with hypertension may receive inadequate financial support. [24] This could affect medication adherence since previous studies have shown a positive association between lower cost of medication and better medication adherence. [25]

Although primary health centers have been proven effective in early diagnosis and management of hypertension, there are no systematic guidelines and rules for hypertensive case management at the community level in China, which may lead to low medication adherence among hypertensive patients. Some community-level studies conducted in China have shown that adherence with drug regimens is lower than 50%. [26] Regular health checks and blood pressure tests are not implemented or included in the health insurance package nationally, although some studies have shown their effectiveness in early diagnosis and management of hypertension. [27]

The main limitation of this study is that no probability sampling information is available in the CHNS. [7] This will affect the accuracy of trend analysis, but has little effect on logistic regression analysis since we used sub-samples instead of the whole sample, and merged samples in different waves, making it impossible to apply sampling weights even where they are available. Provinces involved in this study were mostly located in the northeast and middle part of China, so there were no samples from the richest and poorest provinces. However, the nine provinces chosen in this study range from the wealthiest to the poorest five, and may be relatively representative of the national income distribution. [28] Another limitation is lack of information about the method used to measure blood pressure, which may vary by wave and district. We did not include the types of health insurance in our models because the proportion of missing data on this information is too high. Also the variables we used in this study are not comprehensive, and other unobserved characteristics such as physical activity could also effect the management of hypertension. Last but not least, there is no detailed information on the methods used to recruit new participants in the CHNS, so the new households added in the sample units might not be randomly selected, although these new units should be randomly selected.

This study suggests that China’s health insurance system has been effective in increasing hypertension treatment but that more needs to be done to improve effective coverage of hypertension control. Primary health care center involvement in health education, regular community-based screening, especially for high risk populations such as elderly men, and promotion of medication adherence should be considered where these interventions can be shown to be cost-effective. Also, lifestyle interventions such as reducing daily salt intake that have been proven effective in reducing blood pressure in Japan, [29] should also be considered in China. By improving public health and preventive measures in the current health insurance package, the Chinese government can act early and effectively to prevent the most serious consequences of this challenging and growing non-communicable disease epidemic.

Supporting Information

Acknowledgments

This study was supported in part by grants from the Japan Ministry of Health and Welfare (H25-chikyukibo-ippan-007 and H27-chikyukibo-shitei-004) and the Ministry of Education, Culture, Sports, Science and Technology (Grant-in-aid for scientific research A, grant number 22390130). The funders had no influence over the content of the research or the decision to publish. We are grateful to the National Institute of Nutrition and Food Safety, China Center for Disease Control and Prevention, Carolina Population Center, the University of North Carolina at Chapel Hill, the NIH (R01-HD30880, DK056350, and R01-HD38700) and the Fogarty International Center, NIH for financial support for the CHNS data collection and analysis files from 1989 to 2006 and both parties plus the China-Japan Friendship Hospital, Ministry of Health for support for CHNS 2009 and future surveys.