Chest
SELECTED REPORTSA Case of Precocious Emphysema and Lung Cancer in a Woman With a History of Hypocomplementemic Urticarial Vasculitis
Section snippets
Case Report
A 41-year-old woman presented to the clinic with a 7-year history of progressive dyspnea. She had no cough or mucous production but did occasionally have wheezing.
Her medical history was significant for recurrent episodes of urticaria, angioedema, and arthralgias beginning at age 30 years. A single episode of autoimmune hemolytic anemia and an intermediate antinuclear antibody titer prompted consideration of a diagnosis of systemic lupus erythematosus (SLE). Over time, clinical criteria for
Discussion
McDuffie and colleagues1 first described the uncommon entity of hypocomplementemic urticarial vasculitis syndrome (HUVS) in 1973. They suggested that in order to establish the diagnosis that patients have two major criteria: urticaria of > 6 months in duration and hypocomplementemia; plus two minor criteria: dermal venulitis by biopsy, arthralgia or arthritis, glomerulonephritis, uveitis or episcleritis, recurrent abdominal pain, and a positive C1q precipitin test result. Additional clinical
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Cited by (16)
Hypocomplementemic urticarial vasculitis
2018, Revue de Medecine InterneUrticarial lesions: If not urticaria, what else? The differential diagnosis of urticaria. Part II. Systemic diseases
2010, Journal of the American Academy of DermatologyCitation Excerpt :Among these, the most common are autoimmune connective tissue diseases (particularly SLE,19,20,48-55 but also systemic sclerosis,56 Gougerot–Sjögren syndrome,57 and paraneoplastic dermatomyositis58), followed by infections (mainly chronic or acute viral hepatitis59-64 and sporadic reports of Epstein–Barr virus,65 Mycoplasma pneumoniae,66 and Lyme disease67) and inflammatory bowel diseases.68 In some cases, UV can be a paraneoplastic manifestation, mainly associated with hematologic malignancies, including mostly non-Hodgkin B-cell lymphomas,69-71 monoclonal gammopathies/myeloma,72-74 anecdotal cases of Castleman disease,75 and polycythemia rubra vera,76 but also with various solid neoplasms (non–small cell lung cancer,77 renal cancer,78 testicular teratoma,79 colon adenocarcinoma,80 and nasopharyngeal carcinoma58). Finally, the vasculitic process that causes skin lesions can also involve internal organs, particularly the joints, kidneys, and lungs, and also the gastrointestinal tract and central and peripheral nervous systems.
Hypocomplementemic urticarial vasculitis syndrome presenting with bilateral scleritis
2021, BMJ Case ReportsA severe COPD course: Hypocomplementemic urticaria vasculitis syndrome. A case report
2019, Atemwegs- und Lungenkrankheiten
The authors have no conflicts of interest to disclose.