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Clinical Investigations: CardiologyDiagnostic and Prognostic Value of Myocardial Scintigraphy With Thallium-201 and Gallium-67 in Cardiac Sarcoidosis
Section snippets
METHODS
A patient population consisted of 25 patients who underwent thallium-201 scintigraphy in our hospital between 1988 and 1992. Sarcoidosis was diagnosed by pulmonologists in all patients except one whose condition was diagnosed by dermatologists on skin biopsy specimen. All the patients had no history of ischemic heart disease and no evidence of previous myocardial infarction on resting ECG. Myocardial thallium-201 scintigraphy was performed in all patients. After an overnight fast, 111 MBq of
RESULTS
A summary of the clinical findings is presented in Tables 1 and 2. The proportions of the patients with any kind of abnormalities on ECG and ambulatory ECg, and mean levels of serum ACE and lysozyme were not significantly different between two groups (p>0.05). The proportion of the patients with an enlarged CTR on chest radiographs was significantly higher in group A than in group B (p<0.05). Conversely, the proportion of BHL was significantly lower in group A than in group B (p<0.01) (Table 3).
DISCUSSION
In this study, when cardiac involvements of sarcoidosis were diagnosed according to the findings of myocardial thallium-201 scintigraphy, other findings of noninvasive examinations, including BHL, any kind of conduction block, ventricular arrhythmias, and serum ACE and lysozyme levels were not useful for detecting cardiac sarcoidosis. Although the frequency of an enlarged CTR was significantly higher in group A (consisting of patients with myocardial thallium-201 defects), the findings of
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Revision accepted June 8.
Reprint requests: Dr. Okayama, Third Dept. of Internal Medicine, Hamamatsu University, 3600 Handa-Cho, Hamamatsu, 431–31 Japan