Chest
Original ResearchHealth-Related Quality of LifeRelationship Between Lung Function Impairment and Health-Related Quality of Life in COPD and Interstitial Lung Disease
Section snippets
Study Design
Since September 2005, the LTRC has been enrolling patients with COPD or ILD from four clinical centers: Mayo Clinic (Rochester, Minnesota), University of Colorado, University of Michigan, and University of Pittsburgh. Inclusion criteria are age ≥ 21 years and (1) clinical indication of ILD leading to surgical lung biopsy, (2) diagnosis of COPD leading to treatment with lung volume reduction surgery, (3) diagnosis of ILD or COPD in patients listed for lung transplantation, or (4) lung nodule or
Patient Characteristics
Compared with patients with COPD, patients with ILD were younger and had greater diversity with respect to race and ethnicity (Table 1). However, the majority of patients in both groups were Caucasian. A higher proportion of patients with ILD had diabetes, and more patients with COPD had a history of cancer.
Among patients with ILD, the most common diagnosis was idiopathic pulmonary fibrosis (IPF) (n = 239, 59.0%), followed by hypersensitivity pneumonitis (n = 45, 11.1%) and nonspecific
Discussion
The main finding of this study is that patients with ILD have worse HRQL scores compared with those with COPD with similar severity of ventilatory impairment as assessed by FEV1. This was true for both a respiratory disease-specific measure of HRQL (SGRQ) and a generic measure of HRQL (SF-12 PCS). The mechanism causing this difference is unclear but may be related to differences in disease pathophysiology. Patients with ILD experience a concomitant decline in FEV1 and FVC as a result of
Acknowledgments
Author contributions: Dr Berry is the guarantor of this manuscript and is responsible for this work as a whole, from inception to publication.
Dr Berry: contributed to conception, hypotheses delineation, study design, data analysis, results interpretation, and writing and revision of the manuscript.
Dr Drummond: contributed to conception, hypotheses delineation, study design, data analysis, results interpretation, and writing and revision of the manuscript.
Dr Han: contributed to the conception,
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Funding/Support: This study was supported by the National Institutes of Health [Grant 1KL2RR025006-01] and the National Heart, Lung, and Blood Institute [Grant NO1-HR-46164].
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