Chest
Original ResearchAsthmaMediator Effect of Depressive Symptoms on the Association Between BMI and Asthma Control in Adults
Section snippets
Participants
The current results are a subanalysis of a larger project (the Psychological Risk Factors for Asthma Longitudinal study) that examined the psychologic risk factors for asthma morbidity. Details of the methodology are described elsewhere.19, 20 Briefly, consecutive adult patients with asthma presenting to the asthma clinic of the Hôpital du Sacré-Cœur de Montréal were recruited. Participants had to have been given a primary diagnosis of asthma as demonstrated by methacholine challenge,
Participant Characteristics
Participant characteristics are presented as counts and percentages or mean ± SD for categorical and continuous variables, respectively (Tables 1, 2). The overall sample was predominantly female and middle aged. Most were married or cohabitating, were employed, and had a high school education. Few were current smokers, although more than one-half had a history of smoking. Overall, the sample was moderately overweight (BMI adjusted, 28.3 ± 5.2 kg/m2; range, 17.0-46.8 kg/m2) and minimally
Discussion
The purpose of this study was to clarify the nature of the relationship between BMI and asthma control by concurrently examining the mediational role of depressive symptoms. As predicted, having a higher BMI was associated with worse asthma control. Results also indicated that patients with high levels of depressive symptoms had worse asthma control. Consistent with expectations, the relationship between BMI and asthma control was completely and uniquely mediated by depressive symptoms. That
Acknowledgments
Author contributions: K. L. L. had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. M. B., S. L. B., and K. L. L. contributed to the study concept and design; M. B. and S. L. B. contributed to the data analysis and interpretation; and M. B., S. L. B., K. O., A. J., and K. L. L. contributed to the drafting and review of the manuscript for important intellectual content.
Financial/nonfinancial disclosures: The
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FUNDING/SUPPORT: Direct funding support for this study was provided by the Social Sciences and Humanities Research Counsel of Canada. Additional support was received from the Fonds de la recherche en santé du Québec (FRSQ) (Chercheur-boursier awards to Drs Bacon and Lavoie; scholarships to Mss Boudreau, Ouellet, and Jacob), the Canadian Institutes of Health Research (New Investigator awards to Drs Bacon and Lavoie; scholarship to Ms Boudreau), the FRSQ Respiratory Health Network (scholarship to Ms Boudreau), and the Fonds Québecois de la recherche sur la société et la culture (scholarship to Ms Jacob).
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