Chest
Clinical InvestigationsAirway Involvement in Ulcerative Colitis
Section snippets
Case 1
A 24-year-old construction worker was hospitalized in March 1983 for investigation of nausea, malaise, weight loss, abdominal pain, and bloody bowel movements. Initial investigations, including a barium enema and sigmoidoscopy with biopsy, established the diagnosis of ulcerative colitis. Sulfasalazine, 8 g per day, and prednisone, 20 mg per day, was begun with control of symptoms achieved over three months. Maintenance therapy consisted of sulfasalazine, 4 g per day, and prednisone, 7.5 mg on
Discussion
Although lung disease is recognized in association with ulcerative colitis, it is unusual for it to be symptomatically apparent. In a series of 1,400 patients with inflammatory bowel disease evaluated retrospectively at one center,3 three had unexplained bronchopulmonary disease. More recently, evaluation of unselected patients with ulcerative colitis has demonstrated an asymptomatic decrease in diffusing capacity.5 Two series in the literature describe more specific conducting airway
ACKNOWLEDGMENT
The authors wish to thank Dr. W. Thurlbeck and Dr. J. C. Hogg for their ideas and assistance in the preparation of this manuscript.
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Manuscript received September 23; revision accepted December 2.