Review Articles
The Role of B-Cells in Heart Failure
Authors:
- Andrea M. Cordero-ReyesEmail Andrea M. Cordero-Reyes
- Keith A. Youker
- Guillermo Torre-Amione
Abstract
Heart failure is a complex disease that has great impact on morbidity and mortality in the general population. No recent therapies have proven to be effective; however, the discovery of new potential pathophysiological mechanisms involved in heart failure expression and progression could offer novel therapeutic strategies. A number of studies have shown that the immune system may be a central mediator in the development and progression of heart failure, and here we describe how the B-cell and B-cellmediated pathways play specific roles in the heart failure state. Therapies aimed at B-cells, either blocking antibody productionor inactivating B-cell function, may suggest potential new treatment strategies.
- Year: 2013
- Volume: 9 Issue: 1
- Page/Article: 15-19
- DOI: 10.14797/mdcj-9-1-15
- Published on 1 Jan 2013
- Peer Reviewed