Comparison of the IgG Subclass Distribution of Anti-thyroid Peroxidase Antibodies in Healthy Subjects with That in Patients with Chronic Thyroiditis

YOICHI KOHNO; MASAMI KIJIMA; FUMIHIRO YAMAGUCHI; KIMIYUKI SAITO; HAJIME TSUNOO; TOICHIRO HOSOYA; HIROO NIIMI

doi:10.1507/endocrj.40.317

YOICHI KOHNO, MASAMI KIJIMA, FUMIHIRO YAMAGUCHI, KIMIYUKI SAITO, HAJIME TSUNOO, TOICHIRO HOSOYA, HIROO NIIMI

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Keywords: Anti-thyroid peroxidase antibody, Chronic thyroiditis, IgG subclass, Natural antibody, Thyroid peroxidase

JOURNAL FREE ACCESS

1993 Volume 40 Issue 3 Pages 317-321

DOI https://doi.org/10.1507/endocrj.40.317

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Abstract

The IgG subclass distribution of anti-thyroid peroxidase (TPO) antibodies in patients with chronic thyroiditis and in healthy subjects has been investigated. Anti-TPO antibodies in sera of patients with chronic thyroiditis were predominantly associated with IgG1, with a lesser contribution by IgG4 and IgG3. In contrast, anti-TPO antibodies of healthy subjects were exclusively associated with IgG4. Since structural differences in IgG subclasses reflect differences in their biological roles, these findings suggest that the role of anti-TPO antibodies in patients may differ from that in healthy subjects.

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