Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
ORIGINALS
Anti-Alpha-Enolase Antibodies in Pituitary Disease
Susumu TANAKAKe-ita TATSUMIToru TAKANOYoshio MURAKAMIToshihiro TAKAONoriyoshi YAMAKITAShigeyuki TAHARAAkira TERAMOTOKozo HASHIMOTOYuzuru KATONobuyuki AMINO
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2003 Volume 50 Issue 6 Pages 697-702

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Abstract

A previous study reported a high prevalence of autoantibodies to alpha-enolase in lymphocytic hypophysitis and these antibodies efficiently distinguished lymphocytic hypophysitis from pituitary tumors. To confirm this, we examined autoantibodies to alpha-enolase in patients with lymphocytic hypophysitis (n = 17), pituitary non-functioning adenoma (n = 13), other pituitary diseases (n = 17) and other autoimmune diseases (n = 30), and compared to healthy controls (n = 46). Autoantibodies were found in 41.2%, 46.2%, 23.5%, 20.0% and 4.3%, respectively. Our findings indicate that detection of anti-alpha-enolase antibodies is not suitable for specific diagnosis of lymphocytic hypophysitis.

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© The Japan Endocrine Society
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