Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes

Seong-Su Moon; Young-Sil Lee; Jung-Guk Kim; Su-Won Kim; Ji-Yun Jeong; Eon-Ju Jeon; Hyun-Ae Seo; Soo Heon Kwak; Kyong Soo Park; In-Kyu Lee

doi:10.1507/endocrj.EJ11-0035

ORIGINALS

Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes

Seong-Su Moon, Young-Sil Lee, Jung-Guk Kim, Su-Won Kim, Ji-Yun Jeong, Eon-Ju Jeon, Hyun-Ae Seo, Soo Heon Kwak, Kyong Soo Park, In-Kyu Lee

Author information

Seong-Su Moon
Department of Internal medicine, Dongguk University School of Medicine, Gyeongju, South Korea
Young-Sil Lee
Department of Internal medicine, Dongguk University School of Medicine, Gyeongju, South Korea
Jung-Guk Kim
Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Daegu, South Korea
Su-Won Kim
Departments of Internal Medicine and Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, South Korea
Ji-Yun Jeong
Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Daegu, South Korea
Eon-Ju Jeon
Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Daegu, South Korea
Hyun-Ae Seo
Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Daegu, South Korea
Soo Heon Kwak
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
Kyong Soo Park
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea
In-Kyu Lee
Department of Endocrinology and Metabolism, Kyungpook National University Hospital, Daegu, South Korea
WCU program, Kyungpook National University School of Medicine, Daegu, South Korea
Research Institute of Aging and Metabolism, Kyungpook National University, Daegu, South Korea

Keywords: 11β-hydroxysteroid dehydrogenase type 1, Hexose-6-phosphate dehydrogenase, Single nucleotide polymorphism, Metabolic syndrome, Type 2 diabetes

JOURNAL FREE ACCESS

2011 Volume 58 Issue 11 Pages 949-959

DOI https://doi.org/10.1507/endocrj.EJ11-0035

View "Advance Publication" version (August 23, 2011).

Details

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive glucocorticoid to active glucocorticoid, plays a critical role in the pathogenesis of visceral obesity, metabolic syndrome, and diabetes. Hexose-6-phosphate dehydrogenase (H6PD) supplies a crucial cofactor, reduced nicotinamide adenine dinucleotide phosphate (NADPH), which allows HSD11B1 to maintain reductase activity. The association of common SNPs in HSD11B1 [IVS3-29G/T (rs12086634), IVS4-11120A/G (rs1000283)] and H6PD [R453Q (rs6688832), P554L (rs17368528)], either separately or combined, with type 2 diabetes and metabolic syndrome was examined in 427 Korean subjects with type 2 diabetes and in 358 nondiabetic Korean subjects. HSD11B1 polymorphisms (rs12086634 and rs1000283) were associated with metabolic syndrome among type 2 diabetic subjects and an H6PD polymorphism (rs17368528) was a risk factor for metabolic syndrome in nondiabetic subjects. However, no significant association of these SNPs with type 2 diabetes and metabolic syndrome was found after considering the multiple comparisons in the total study population. In conclusion, HSD11B1 and H6PD polymorphisms may not be associated with type 2 diabetes and metabolic syndrome. Further investigation of the role of these gene polymorphisms on the pathogenesis of metabolic syndrome is required.

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