The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome

Aydogan Aydogdu; Gokhan Uckaya; Ilker Tasci; Oben Baysan; Serkan Tapan; Baris Bugan; Muhittin Serdar; Halil Akbulut; Umit Aydogan; Alper Sonmez; Sebnem Aydogdu; Mustafa Kutlu

doi:10.1507/endocrj.EJ11-0328

ORIGINALS

The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome

Aydogan Aydogdu, Gokhan Uckaya, Ilker Tasci, Oben Baysan, Serkan Tapan, Baris Bugan, Muhittin Serdar, Halil Akbulut, Umit Aydogan, Alper Sonmez, Sebnem Aydogdu, Mustafa Kutlu

Author information

Aydogan Aydogdu
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara 06018, Turkey
Gokhan Uckaya
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara 06018, Turkey
Ilker Tasci
Deparment of Internal Medicine, Gulhane School of Medicine, Ankara 06018, Turkey
Oben Baysan
Deparment of Cardiology, Gulhane School of Medicine, Ankara 06018, Turkey
Serkan Tapan
Department of Biochemistry, Gulhane School of Medicine, Ankara 06018, Turkey
Baris Bugan
Deparment of Cardiology, Gulhane School of Medicine, Ankara 06018, Turkey
Muhittin Serdar
Department of Biochemistry, Gulhane School of Medicine, Ankara 06018, Turkey
Halil Akbulut
Deparment of Family Medicine, Gulhane School of Medicine, Ankara 06018, Turkey
Umit Aydogan
Deparment of Family Medicine, Gulhane School of Medicine, Ankara 06018, Turkey
Alper Sonmez
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara 06018, Turkey
Sebnem Aydogdu
Deparment of Internal Medicine, Mevki Military Hospital, Ankara 06018, Turkey
Mustafa Kutlu
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara 06018, Turkey

Keywords: Polycystic ovary syndrome, Epicardial adipose tissue thickness, Adiponectin, Insulin resistance, Cardiovascular disease

JOURNAL FREE ACCESS

2012 Volume 59 Issue 6 Pages 509-516

DOI https://doi.org/10.1507/endocrj.EJ11-0328

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Details

Abstract

The amount of epicardial adipose tissue (EAT), a component of body visceral adiposity, has been linked to the presence and severity of cardiovascular disease through multiple mechanisms. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and subclinical inflammation, which participate in the mechanism of atherosclerosis. We searched if the patients with PCOS have increased EAT thickness (EATT), along with its relation to the measures of adiposity and insulin sensitivity. A total of 41 subjects with PCOS and 46 age and body mass index (BMI) matched healthy controls were enrolled. EAT was measured by echocardiography above the free wall of the right ventricle. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) formula, and plasma adiponectin level was measured by ELISA. Compared to healthy controls EATT and HOMA-IR score were significantly higher (p=0.0001 for both) while plasma adiponectin concentration was significantly lower (p=0.048) in women with PCOS. EATT correlated positively with total cholesterol, triglyceride, luteinizing hormone (LH) and negatively with sex hormon binding globuline (p<0.05 for all), whereas it displayed no correlation to plasma adiponectin level (p=0.924). Triglyceride level was the significant determinant of EATT in logistic regression analysis (p=0.035). Thickness of the EAT is increased in patients with PCOS in conjunction with hyperandrogenity. Prospective studies are required to identify the relation of EAT and cardiovascular risk in patients with PCOS.

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