Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors

Takeshi Kondo; Itsuro Endo; Ken-ichi Aihara; Yukiyo Onishi; Bingzi Dong; Yukari Ohguro; Kiyoe Kurahashi; Sumiko Yoshida; Yuichi Fujinaka; Akio Kuroda; Munehide Matsuhisa; Seiji Fukumoto; Toshio Matsumoto; Masahiro Abe

doi:10.1507/endocrj.EJ15-0589

ORIGINALS

Serum carboxy-terminal telopeptide of type I collagen levels are associated with carotid atherosclerosis in patients with cardiovascular risk factors

Takeshi Kondo, Itsuro Endo, Ken-ichi Aihara, Yukiyo Onishi, Bingzi Dong, Yukari Ohguro, Kiyoe Kurahashi, Sumiko Yoshida, Yuichi Fujinaka, Akio Kuroda, Munehide Matsuhisa, Seiji Fukumoto, Toshio Matsumoto, Masahiro Abe

Author information

Takeshi Kondo
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Itsuro Endo
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Ken-ichi Aihara
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Yukiyo Onishi
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Bingzi Dong
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Yukari Ohguro
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Kiyoe Kurahashi
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Sumiko Yoshida
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan
Yuichi Fujinaka
Department of Internal Medicine, Local Incorporated Administrative Agency, Tokushima Prefecture Naruto Hospital, Naruto 772-0001, Japan
Akio Kuroda
Diabetes Therapeutics and Research Center, Tokushima University, Tokushima 770-8503, Japan
Munehide Matsuhisa
Diabetes Therapeutics and Research Center, Tokushima University, Tokushima 770-8503, Japan
Seiji Fukumoto
Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan
Toshio Matsumoto
Fujii Memorial Institute of Medical Sciences, Tokushima University, Tokushima 770-8503, Japan
Masahiro Abe
Department of Hematology, Endocrinology & Metabolism Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima 770-8503, Japan

Keywords: ICTP, Atherosclerosis, Max IMT, baPWV

JOURNAL FREE ACCESS

2016 Volume 63 Issue 4 Pages 397-404

DOI https://doi.org/10.1507/endocrj.EJ15-0589

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Abstract

Carboxy-terminal telopeptide of type I collagen (ICTP) is generated through matrix metalloproteinase (MMP)-dependent type I collagen digestion, and has been widely utilized as a biomarker for bone turnover. The fact that atherosclerotic lesions are rich in both type I collagen and MMP-producing macrophages led to the hypothesis that serum ICTP concentrations may serve as a non-invasive clinical biomarker for atherosclerosis. Therefore, the association of serum ICTP concentrations with the maximum intima-media thickness (IMT) of carotid arteries, a surrogate index of systemic atherosclerosis, or brachial-ankle pulse wave velocity (baPWV) in patients with atherosclerotic risk factors was evaluated. A total of 52 male and 65 female (mean age: 62.8 yrs) patients without renal failure, malignancies or bone diseases known to affect serum ICTP concentrations were recruited. Patients with max IMTs ≥1.1 mm showed significantly higher serum ICTP concentrations compared with patients with max IMTs <1.1 mm (3.33 ± 0.97 vs 2.82 ± 0.65 ng/mL, p<0.05). Serum ICTP concentration was also positively correlated with max IMT (p<0.001) or baPWV values (p<0.05). Multivariate analyses also revealed that serum ICTP concentrations were correlated with max IMT (p<0.001; 95% CI 0.200 to 0.454). These results suggest that serum ICTP concentrations can be used as a non-invasive biomarker for systemic atherosclerosis.

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