Endocrine Journal
Online ISSN : 1348-4540
Print ISSN : 0918-8959
ISSN-L : 0918-8959
ORIGINALS
Hypopituitarism in a patient with transsphenoidal cephalocele: longitudinal changes in endocrinological abnormalities
Keiji Tanimoto, Saori Onda, Hideaki Sawaki, Tetsuya Hiraiwa, Hiroyuki Sano, Mineki Ohnishi, Jungo Terasaki, Toshiaki Hanafusa
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Keywords: Hypothalamic-pituitary dysfunction, Panhypopituitarysm, Pituitary herniation, Follow-up, MRI
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2011 Volume 58 Issue 3 Pages 193-198

View "Advance Publication" version (February 17, 2011).
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Abstract

We report a 21-year-old man with severe fatigue due to hypopituitarism. At the age of 6 years, he was diagnosed with short stature due to a GH deficiency accompanied by a sphenoid cystic lesion. Laboratory findings and provocative tests for pituitary hormone function revealed ACTH, LH, FSH, TSH, and GH deficiency. Computed tomography and magnetic resonance imaging revealed transsphenoidal cephalocele due to a defect in the floor of the sella turcica. At 6 years, he only had severe GH deficiency and poor response of LH to LHRH. Hypothalamic-pituitary dysfunction and pituitary herniation have progressed subsequently; we observed a longitudinal progression of hypothalamic-pituitary dysfunction caused by transsphenoidal cephalocele. This dysfunction requires the selection of a treatment that will not aggravate the condition further.

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Endocrinologia Japonica

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