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Licensed Unlicensed Requires Authentication Published by De Gruyter August 9, 2007

Global standardization of glycated hemoglobin measurement: the position of the IFCC Working Group

  • International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) IFCC Scientific Division, Working Group on Standardization of HbA1c (WG-HbA1c): Andrea Mosca , Ian Goodall , Tadao Hoshino , Jan O. Jeppsson , W. Garry John , Randie R. Little , Kor Miedema , Gary L. Myers , Hans Reinauer , David B. Sacks and Cas W. Weykamp

Abstract

The measurement of glycated hemoglobin is central in the monitoring of glycemic control in patients with diabetes. There are at least 30 different laboratory assays commercially available to measure the proportion of HbA1c in blood. In 1995 the IFCC established a Working Group (IFCC WG-HbA1c) to achieve international standardization of HbA1c measurement. The main achievements can be summarized as follows: a) a reference measurement procedure has been established with purified primary calibrators; b) a network of reference laboratories has been developed worldwide; and c) work has begun on implementation of traceability to the IFCC reference system. The IFCC WG-HbA1c recognizes the recommendation of the IFCC-IUPAC Committee on Nomenclature, Properties and Units that the analyte measured by the IFCC reference measurement procedure has been defined as βN1-deoxyfructosyl-hemoglobin and that the recommended measurement units are mmol/mol. The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice.

Clin Chem Lab Med 2007;45:1077–80.


Corresponding author: Dr. W. Garry John, Norfolk and Norwich University Hospital, School of Medicine, Health Policy and Practice, UEA, Norwich, UK

Published Online: 2007-08-09
Published in Print: 2007-08-01

©2007 by Walter de Gruyter Berlin New York

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