Abstract
A nested PCR was used to detect TTV DNA in serum from 490 mother-infant pairs to determine the rate of vertical transmission of TTV in Guangzhou City, P.R. China. TTV DNA was positive in 87 mothers and 12 of their babies, giving a prevalence of 17.8% in pregnant women and a mother-to-child transmission rate of 13.8%. In eight mother-infant pairs, TTV DNA nucleotide sequences from the mothers and their corresponding infants were identical. The homology of Guangzhou TTV and Japanese TTV ranged from 85.3%–98.2% at nucleotide level. TTV infection is common in pregnant women in South China and vertical transmission can occur. Guangzhou’s and Japanese TTV isolates belong to the same genotype.
References
1 Bagaglio S, G Sitia, D Prati, D Cella, H Hasson, R Novati, A Lazzarin, G Morsica: Mother-to-child transmission of TT virus: Sequence analysis of non-coding region of TT virus in infected mother-infant pairs. Arch Virol147 (2002) 803Search in Google Scholar
2 Chen H, YL Wang, FG Qiu, LL Zhuang, YR Lin: Study on TT virus infection of pregnant women and their infant. Chin J Gynecol Obstet35 (2000) 277Search in Google Scholar
3 Gerner P, R Oettinger, W Gerner, J Falbrede, S Wirth. Mother-to-infant transmission of TT virus: prevalence, extent and mechanism of vertical transmission. Pediatr Infect Dis J19 (2000) 1074Search in Google Scholar
4 Iso K, Y Suzuki, M Takayama: Mother-to-infant transmission of TT virus in Japan. Int J Gynecol Obstet75 (2001) 11Search in Google Scholar
5 Nishizawa T, H Okamoto, K Konishi, H Yoshizawa, Y Miyakawa, M Mayumi: A novel DNA virus (TTV) associated with elevated transaminase levels in post transfusion hepatitis of unknown etiology. Biochem Biophys Res Commun241 (1997) 92Search in Google Scholar
6 Okamoto H, T Nishizawa, N Kato. Molecular cloning and characterization of a novel DNA virus (TTV) associated with post transfusion hepatitis of unknown etiology. Hepatol Res10 (1998) 1Search in Google Scholar
7 Saback FL, SA Gomes, VS de Paula, RR da Silva, LL Lewis-Ximenez, C Niel: Age-specific prevalence and transmission of TT virus. J Med Virol59 (1999) 318Search in Google Scholar
8 Schroeter M, HH Feucht, B Zoellner, B Knoedler, P Schaefer, L Fischer, R Laufs: Prevalence of TTV viremia among healthy subjects and individuals at risk for parenterally transmitted disease in Germany. Hepatology Research13 (1999) 205Search in Google Scholar
9 Takahashi K, H Hoshino, Y Ohta, N Yoshida, S Mishiro: Very high prevalence of TT virus (TTV) infection in general population of Japan revealed by a new set of PCR primers. Hepatology Research12 (1998) 233Search in Google Scholar
10 Thom K, C Morrison, JC Lewis, P Simmonds: Distribution of TT virus (TTV), TTV-like minivirus, and related viruses in humans and nonhuman primates. Virology306 (2003) 324Search in Google Scholar
11 Xiao X, XG Zhou, X Chen, AH Xiong, XJ Mao: Transfusion transmitted virus in pregnant women and its mother-to-infant vertical transmission. Chin J Perinat Med3 (2000) 156Search in Google Scholar
12 Zhou B, WM Ma, HS Wang, LM Xu, J Yuan, YS Fu, T Sun: Investigation on TT virus populations in Shenzhen, Clin J Exp Virol12 (1998) 241Search in Google Scholar
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