The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Case Report
Tubulointerstitial Nephritis and Uveitis Syndrome in Two Siblings
Hiroshi Tanaka, Shinobu Waga, Tohru Nakahata, Koichi Suzuki, Tatsuo Ito, Norio Onodera, Senjo Iwami, Nobuhiro Monma, Etsuro Ito
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Keywords: helper/inducer T cell infiltration, HLA-DR6, siblings, tubulointerstitial nephritis and uveitis syndrome, urinary β-2 microglobulin
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2001 Volume 194 Issue 1 Pages 71-74

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Abstract

Two Japanese sisters with persistent uveitis showed significant increased levels of urinary β-2 microglobulin. A percutaneous renal biopsy performed in the younger sister revealed tubulointerstitial nephritis (TIN) with helper/inducer T cell infiltrates. Also, abnormal 67-gallium accumulation in the kidneys, suggesting TIN, was observed in the other one at the same time. Although patients with the syndrome of tubulointerstitial nephritis and uveitis (TINU) have been reported to date, its occurrence in siblings has rarely been seen. Both of them shared same human leukocyte antigen (HLA) DR6, suggesting the potential association between HLA-DR6 and TINU.

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