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Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma

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Abstract

Objective

To assess the clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma (EOC).

Methods

A retrospective study of young EOC inpatients (≤40 years old) was performed during January 1994 and December 2010 in eight institutions.

Results

Data were analyzed from 94 patients treated with fertility-sparing surgery with a median follow-up time of 58.7 months. As histologic grade increased, overall survival (OS) and disease-free survival (DFS) of patients receiving fertility-sparing surgery declined. Neither staging surgery nor laparoscopy of early stage EOC with conservative surgery had a significant effect on OS or DFS. Normal menstruation recommenced after chemotherapy in 89% of the fertility-sparing group. Seventeen pregnancies among twelve patients were achieved by the end of the follow-ups.

Conclusions

Fertility-sparing treatment for patients with EOC Stage I Grade 1 could be cautiously considered for young patients. The surgical procedure and surgical route might not significantly influence the prognosis. Standard chemotherapy is not likely to have an evident impact on ovarian function or fertility in young patients.

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Authors and Affiliations

  1. Department of Gynecology, Peking University First Hospital, Beijing, 100034, China

    Jun Hu & Li-rong Zhu

  2. Department of Gynecology, Southwest Hospital of Third Military Medical University, Chongqing, 400038, China

    Zhi-qing Liang

  3. Department of Gynecology, Chinese PLA General Hospital & Chinese PLA Postgraduate Medical School, Beijing, 100853, China

    Yuan-guang Meng

  4. Department of Gynecology, Peking University Third Hospital, Beijing, 100191, China

    Hong-yan Guo

  5. Tianjin Central Obstetrics and Gynecological Hospital, Tianjin, 300052, China

    Peng-peng Qu

  6. Department of Gynecology, Xinjiang Medical University First Teaching Hospital, Urumqi, 830054, China

    Cai-ling Ma

  7. Shanghai Red House Hospital of Obstetrics and Gynecology, Shanghai, 200011, China

    Cong-jian Xu

  8. Department of Gynecology, Tianjin Medical University General Hospital, Tianjin, 300052, China

    Bi-bo Yuan

Authors
  1. Jun Hu
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  2. Li-rong Zhu
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  3. Zhi-qing Liang
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  4. Yuan-guang Meng
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  5. Hong-yan Guo
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  6. Peng-peng Qu
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  7. Cai-ling Ma
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  8. Cong-jian Xu
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  9. Bi-bo Yuan
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Correspondence to Li-rong Zhu.

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Hu, J., Zhu, Lr., Liang, Zq. et al. Clinical outcomes of fertility-sparing treatments in young patients with epithelial ovarian carcinoma. J. Zhejiang Univ. Sci. B 12, 787–795 (2011). https://doi.org/10.1631/jzus.B1100166

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  • DOI: https://doi.org/10.1631/jzus.B1100166

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