Abstract
Herpes simplex virus type 1 (HSV-1), a neurotropic member of the alphaherpes virus family, is among the most prevalent and successful human pathogens. HSV-1 can cause serious diseases at every stage of life including fatal disseminated disease in newborns, cold sores, eye disease, and fatal encephalitis in adults. HSV-1 infection can trigger rapid immune responses, and efficient inhibition and clearance of HSV-1 infection rely on both the innate and adaptive immune responses of the host. Multiple strategies have been used to restrict host innate immune responses by HSV-1 to facilitate its infection in host cells. The adaptive immunity of the host plays an important role in inhibiting HSV-1 infections. The activation and regulation of T cells are the important aspects of the adaptive immunity. They play a crucial role in host-mediated immunity and are important for clearing HSV-1. In this review, we examine the findings on T cell immune responses during HSV-1 infection, which hold promise in the design of new vaccine candidates for HSV-1.
中文概要
题目
一型单纯疱疹病毒感染与T 淋巴细胞免疫反应
概要
文章概述了一型单纯疱疹病毒基因组的组成和在 宿主细胞的生活周期,以及感染时引起的与人类 相关的疾病;阐述了一型单纯疱疹病毒感染时引 起的CD4 和CD8 阳性T 淋巴细胞的免疫反应; 以及CD8 阳性T 淋巴细胞的功能耗竭;简要探讨 了一型单纯疱疹病毒的疫苗研发的相关策略和 前景;方便读者理解HSV-1 感染和T 淋巴细胞免 疫的关系。
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Project supported by the Wuhan Institute of Virology (WIV) “One-Three-Five” Strategic Programs, China
ORCID: Bin WEI, http://orcid.org/0000-0002-2731-489X
Dr. Bin WEI, the author of this invited review, is an editorial board member of Journal of Zhejiang University- SCIENCE B (Biomedicine & Biotechnology). He did postdoctoral research at the University of Cambridge and University of Oxford from 2002 to 2009. His main research interests include: (1) design and development of new therapeutic and preventive vaccines; (2) the mechanisms of respiratory inflammation, nerve system inflammation, and tumor-associated inflammation caused by viral infection; (3) the mechanisms of signal transduction mediated by viral invasion receptors and lymphocyte function receptors on viral inflammatory response.
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Zhang, J., Liu, H. & Wei, B. Immune response of T cells during herpes simplex virus type 1 (HSV-1) infection. J. Zhejiang Univ. Sci. B 18, 277–288 (2017). https://doi.org/10.1631/jzus.B1600460
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DOI: https://doi.org/10.1631/jzus.B1600460