Interdigitating dendritic cell sarcoma of the liver and lung: a case report with morphohological and immunohistochemical features of tumor

Svjetlana Radović; Mirsad Dorić; Hamza Žujo; Ajna Hukić; Suada Kuskunović; Mirsad Babić; Ivana Tomić

doi:10.17305/bjbms.2012.2485

Authors

Svjetlana Radović Institute of Pathology, Medical Faculty, University of Sarajevo
Mirsad Dorić Institute of Pathology, Medical Faculty, University of Sarajevo
Hamza Žujo Institute of Forensic Medicine, Medical Faculty, University of Sarajevo
Ajna Hukić Institute of Pathology, Medical Faculty, University of Sarajevo
Suada Kuskunović Institute of Pathology, Medical Faculty, University of Sarajevo
Mirsad Babić Institute of Pathology, Medical Faculty, University of Sarajevo
Ivana Tomić Institute of Pathology, Medical Faculty, University of Sarajevo

DOI:

https://doi.org/10.17305/bjbms.2012.2485

Keywords:

interdigital dendritic cells, sarcoma, extranodal location

Abstract

Interdigitating dendritic cell sarcoma is extremely rare neoplasm that mainly occurs in the lymph nodes. Only 45 cases have been reported in the literature to date.

We report a case of this sarcoma arising from the liver and lung, a previosly unreported site for this neoplasm. An 19-year-old girl deteriorated rapidly after artificial abortion and died 4 weeks later. Autopsy showed markedly enlarged liver and lung with numerous nodules up to 0.5 centimeters in diameter. Microscopically, nodules was composed of large pleomorphic cells that were immunohistochemically positive for proteins S-100 and vimentin, some of them expressed positivity to fascin and CD 68, with a rich small CD3 positive T lymphocytic infiltrateite around them.

Based of these findings, the present case was diagnosed as interdigitating dendritic cell sarcoma, a neoplasm that remains a diagnostic and clinical challenge, because it can mimic a wide variety of other malignant tumors and tumor-like lesions.