Clinical Application of 18F-fluorodeoxyglucose PET and LGE CMR in Cardiac Sarcoidosis

Hiroshi Ohira; Keiichiro Yoshinaga; Osamu Manabe; Noriko Oyama-Manabe; Ichizo Tsujino; Masaharu Nishimura; Nagara Tamaki

doi:10.17996/anc.17-00027

Cardiac Sarcoidosis - From the CME Session at 63rd SNMMI Annual Meeting

Clinical Application of ¹⁸F-fluorodeoxyglucose PET and LGE CMR in Cardiac Sarcoidosis

Hiroshi Ohira, Keiichiro Yoshinaga, Osamu Manabe, Noriko Oyama-Manabe, Ichizo Tsujino, Masaharu Nishimura, Nagara Tamaki

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Keywords: ¹⁸F-fluorodeoxygluocse, Cardiac magnetic resonance imaging, Cardiac sarcoidosis, Late gadolinium enhancement, Patient monitoring

JOURNAL FREE ACCESS

2017 Volume 3 Issue 1 Pages 125-130

DOI https://doi.org/10.17996/anc.17-00027

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Abstract

Sarcoidosis is a multisystem granulomatous disease of unknown etiology that is characterized by the formation of non-caseating granulomas at various sites in the body. Cardiac sarcoidosis (CS) has been underdiagnosed in the past due to a lack of imaging modalities with high sensitivity. CS may cause various symptoms including conduction disturbance, ventricular arrhythmias, cardiac dysfunction and sudden cardiac death, which account for an increased mortality rate in these patients. ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG PET) and late gadolinium-enhanced cardiac magnetic resonance imaging (LGE CMR) have played important roles in the recent guidelines for the diagnosis of CS. Each one possesses its own unique abilities and can contribute to early disease detection, assessment of disease activity, response to treatment, and risk stratification.
However, further studies are necessary in order to establish the standard methods for clinical application of FDG PET and CMR.

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