Regular ArticleGenotype-dependent Down-regulation of Gene Expression and Function of MDR1 in Human Peripheral Blood Mononuclear Cells under Acute Inflammation
References (32)
- et al.
The natural history of corticosteroid therapy for inflammatory bowel disease: a population-based study
Gastroenterology
(2001) - et al.
Severe asthma treatment: need for characterizing patients
Lancet
(2005) The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
Adv. Drug Deliv. Rev.
(2002)MDR1 genotype-related pharmacokinetics: fact or fiction?
Drug Metab. Pharmacokinet.
(2005)- et al.
Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone
J. Biol. Chem.
(1992) - et al.
Allelic variations of the multidrug resistance gene determine susceptibility and disease behavior in ulcerative colitis
Gastroenterology
(2005) - et al.
The MDR1 polymorphisms at exons 21 and 26 predict steroid weaning in pediatric heart transplant patients
Hum. Immunol.
(2002) - et al.
Immunosuppressors and reversion of multidrug resistance
Crit. Rev. Oncol. Hematol.
(2005) - et al.
Competitive interaction of cyclosporines with the Vinca alcaloid-binding site of the P-glycoptrotein in multidrug-resistant cells
J. Biol. Chem.
(1990) - et al.
Determination of P-gp and MRP1 expression and function in peripheral blood mononuclear cells in vivo
J. Immunol. Meth.
(2002)
Pharmacogenetics of drug transporters and its impact on the pharmacotherapy
Curr. Top. Med. Chem.
Pharmacogenetics of MDR1 and its impact on the pharmacokinetics and pharmacodynamics of drugs
Pharmacogenomics
Structural determinants of P-glycoprotein-mediated transport of glucocorticoids
Pharm. Res.
ABCB1 C3435T and G2677T/ A polymorphism decreased the risk for steroid-induced osteonecrosis of the femoral head after kidney transplantation
Pharmacogenetics
The impact of pharmacogenomic factors on steroid dependency in pediatric heart transplant patients using logistic regression analysis
Pediatr. Transplant.
The MDR1 3435 polymorphism in patients with rheumatoid arthritis
Int. J. Clin. Pharmacol. Ther.
Cited by (20)
Association of ABCB1 gene polymorphisms and haplotypes with therapeutic efficacy of glucocorticoids in Chinese patients with immune thrombocytopenia
2014, Human ImmunologyCitation Excerpt :It is widely accepted that genetic factors play a pivotal role in several aspects of ITP despite it is an autoimmune disorder, including susceptibility of this disease [17], and the response to GCs treatment varies from patient to patient [18]. Recently, three SNPs of ABCB1 (C1236T, C3435T and G2677T/A) were proved to be associated with GCs anti-inflammatory effects [19], glucocorticoid receptors [20] and related complications [21]. However, little is known about the roles of these SNPs and haplotypes in GCs curative effects during treatment of ITP.
Host genetic risk factors for community-acquired pneumonia
2013, GeneCitation Excerpt :Although ABCB1 is a well-conserved gene, there is increasing evidence that its polymorphisms affect substrate specificity and may be the expression level and/or stability of its mRNA (Fung and Gottesman, 2009). For example, it has been shown that under experimental acute inflammation ABCB1 mRNA expression is significantly down-regulated in PBMCs (peripheral blood mononuclear cells) obtained from the subjects harboring 3435C in comparison to those without it (Markova et al., 2006). We therefore suggest that during inflammation the fast efflux of drugs in the subjects carrying 3435T/T genotype may contribute to the progression of the disease.
ABCB1 and ABCC1 expression in peripheral mononuclear cells is influenced by gene polymorphisms and atorvastatin treatment
2009, Biochemical PharmacologyCitation Excerpt :Interestingly, the down regulation of the ABCB1 mRNA induced by atorvastatin seems to be dependent on G2677T/A polymorphism suggesting that this SNP plays an important role in regulating ABCB1 expression. On the other hand, reduction of ABCB1 mRNA levels in PBMC in response to lipopolysaccharide (LPS)-induced experimental acute inflammation was found to be associated with ABCB1 C3435T SNP [49]. Genetic factors as contributors to patient’s intervariability in lipid-lowering response to statins have been investigated in aspects of pharmacokinetics (e.g. ABC and SLC transporters, CYPs enzymes, UGT enzymes), pharmacodynamics (e.g. HMGCR, LDLR, CETP, APOA1, APOE, etc.) and disease-related genes (e.g. NOS3, ESR1, LOX-1) [reviewed in [20]].
Synonymous Mutations and Ribosome Stalling Can Lead to Altered Folding Pathways and Distinct Minima
2008, Journal of Molecular Biology