ReviewInvolvement of the Immune System in Idiosyncratic Drug Reactions
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Cited by (51)
Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism
2024, Chemico-Biological InteractionsDesign, synthesis and antitumor activity of novel thiophene-pyrimidine derivatives as EGFR inhibitors overcoming T790M and L858R/T790M mutations
2020, European Journal of Medicinal ChemistryCitation Excerpt :By changing the length of the side chain and the electrophilicity of the group in the deep solvent region, we explored which type of side chain was effective for the activity of the compounds. On the other hand, according to previous studies [17–19], although covalent inhibitors have advantages over their reversible, noncovalent conjugated counterparts, such as improving biochemical efficiency, prolonging the action time, and avoiding the potential of some drug-resistant mechanisms, when covalent inhibitors are highly reactive and/or lack of specificity, covalent modifications in proteins may participate in immunotoxicity and specific hypersensitivity. In previously published literature [20–22], the introduction of small substituents at the end of the acrylamide side chain can change the activity of the reaction between the acrylamide warhead and the amino acid residue CYS797 in the back pocket.
Increased frequency of acute reactions to iodinated contrast media in cancer patients treated with anti-CTLA-4 immunomodulatory antibodies
2018, Medical HypothesesCitation Excerpt :Allergic-like reactions are probably independent of the dose and concentration and induced by alteration of the immune system balance. Conversely, physiologic reactions are frequently dose and concentration-dependent [6,7]. The immune system protects the host from exogenous pathogens by distinguishing “self” from “non-self” using stimulatory and inhibitory components.
The Art and Science of Diagnosing and Managing Drug-induced Liver Injury in 2015 and Beyond
2015, Clinical Gastroenterology and HepatologyCitation Excerpt :Since its inception, millions of searches have been conducted on its contents, with projections that it will continue to expand in its role as the most up-to-date virtual textbook. Although not a specific focus of this review, current research efforts into the mechanisms of DILI are being directed at the role of the intrinsic immune system,86–88 mitochondrial injury,48–50 the bile salt excretory pump,31,89,90 as well as using the fields of metabolomics, transcriptomics, proteomics, etc.91–96 For certain agents such as INH, the long-held mechanisms of injury are being redefined.49,52 Although such efforts have brought us closer to understanding why DILI occurs, gaps in our knowledge base still remain.2,4,17
Mechanism of quinine-dependent monoclonal antibody binding to platelet glycoprotein IIb/IIIa
2015, BloodCitation Excerpt :Parallel behavior of the human and murine antibodies in vitro and in vivo favors the likelihood that findings made with the mAbs are relevant to mechanisms responsible for DITP in patients sensitive to quinine. It is widely thought that drugs or their reactive metabolites usually initiate idiosyncratic sensitivity reactions by binding to an autologous protein and modifying it in such a way that it becomes capable of inducing an immune response.35-39 Quinine does bind weakly to platelets in vitro, probably the result of nonspecific interactions with membranes and membrane proteins, but platelets treated with high doses of quinine and then washed, never bind antibody.18,40