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Update of research on the role of EZH2 in cancer progression
Authors Shen L, Cui J, Liang S, Pang Y, Liu P
Received 7 January 2013
Accepted for publication 17 February 2013
Published 4 April 2013 Volume 2013:6 Pages 321—324
DOI https://doi.org/10.2147/OTT.S42453
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Liang Shen,1 Jing Cui,2 Shumei Liang,3 Yingxin Pang,1 Peishu Liu1
1Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 2Department of Oral and Maxillofacial Surgery, Jinan Stomatologic Hospital, 3Department of Obstetrics and Gynecology, Provincial Hospital Affiliated to Shandong University, Jinan, People’s Republic of China
Abstract: Accumulating evidence shows that enhancer of zeste homolog 2 (E2H2) is upregulated in a broad range of cancer types, such as breast cancer, prostate cancer, ovarian cancer, and colon cancer. Therefore, inhibiting EZH2 expression may be a promising strategy for anticancer therapy. This review focuses on the current understanding of the mechanisms underlying EZH2 regulation that are involved in cancer progression. Also, it introduces two EZH2 inhibitors that target EZH2 and could be potentially applied in the treatment of cancer in the future.
Keywords: EZH2, PRC2, cancer
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