20Jun 2017

COMPARATIVE STUDY BETWEEN MEASUREMENTS OF SERUM CHOLESTEROL, URIC ACID AND GLUCOSE IN CHILDREN WITH β-THALASSEMIA BY LABORATORY AND BEDSIDE METHODS.

  • Pediatric department, Faculty of medicine, Benha University, Egypt.
  • Clinical pathology department, Faculty of medicine, Benha University, Egypt.
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Background: In Egypt, β-thalassemia is the commonest cause of chronic hemolytic anemia, it considered as major public health problem. Methods: This study was a case control study included thirty -thalassemia major children (from 4-18 years) and thirty age and sex matched healthy children with total mean age (7.15). All children were subjected to full medical history taking and full clinical examination. Random blood samples were collected from patient and control groups (5 ml fresh blood) for hematological parameters (CBC, Reticulocyte count). Cholesterol, uric acid and glucose levels were measured twice {laboratory by spectrophotometric method and bedside test using strips of multi-function meter EasyTouch? GCU}. Results: The main complaint of thalassemic children was pallor followed by (diarrhea, vomiting, abdominal enlargement or cough) followed by jaundice. Age at diagnosis was found to range from 9-48 months. Frequency of blood transfusion was found to be twice per month (56.7%). Patients were treated with one of three types of iron chelating agents (FPX?, Desferal? and Exjade?). Hemoglobin (Hb) concentration, Mean corpuscular volume (MCV) were decreased significantly (p<0.05). Mean corpuscular hemoglobin (MCH), Mean corpuscular hemoglobin concentration (MCHC) and platelet (PLT) counts were found to decrease insignificantly in patient group than control group, while reticulocyte count increased significantly in patient group than control. A positive significant correlation (p<0.05) was found between serum ferritin and frequency of blood transfusion and there were no significant differences in serum ferritin levels according to chelating agents used in patient group. Cholesterol level was decreased significantly (P<0.001) in -thalassemia patients than healthy children. Serum uric acid and glucose concentrations were increased significantly in thalassemic patient group than the control group. Conclusion: EasyTouch? GCU multi-function monitoring system promise quick and accurate concentrations of cholesterol, uric acid and glucose compared to traditional laboratory measurements.

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[Ghada Saad Abdelmotaleb, Mohamed Khaled Abdo, Eman R. Abdelmonaem, Enas Sebaey Ahmed and Ahmed Aboelsoued. (2017); COMPARATIVE STUDY BETWEEN MEASUREMENTS OF SERUM CHOLESTEROL, URIC ACID AND GLUCOSE IN CHILDREN WITH β-THALASSEMIA BY LABORATORY AND BEDSIDE METHODS. Int. J. of Adv. Res. 5 (Jun). 963-973] (ISSN 2320-5407). www.journalijar.com

Ahmed Aboelsoued Mohamed
Pediatric Resident

DOI:

Article DOI: 10.21474/IJAR01/4498      
DOI URL: http://dx.doi.org/10.21474/IJAR01/4498

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