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Age-Related Changes in Liver Size and Hepatic Blood Flow

The Influence on Drug Metabolism in the Elderly

  • Review Article
  • Clinical Pharmacokinetics and Disease Processes
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Summary

The propensity of elderly people to suffer from dose-dependent adverse drug reactions is well known. This may be largely related to reduced drug clearance. Changes in liver size and liver blood flow are probably the main reason for this decline in drug elimination with age. This review focuses on methods of measuring liver size and blood flow, on changes which have been reported in the elderly and on the clinical implications of these changes.

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  1. Geriatric Pharmacology Research Group, Department of Medicine (Geriatrics) and Clinical Pharmacology, University of Newcastle upon Tyne, England

    K. W. Woodhouse & H. A. Wynne

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  1. K. W. Woodhouse
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  2. H. A. Wynne
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Woodhouse, K.W., Wynne, H.A. Age-Related Changes in Liver Size and Hepatic Blood Flow. Clin-Pharmacokinet 15, 287–294 (1988). https://doi.org/10.2165/00003088-198815050-00002

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