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Drugs
Erschienen in: Drugs 3/2009

01.02.2009 | Adis Drug Profile

Transdermal Oxybutynin

verfasst von: Claudine M. Baldwin, Gillian M. Keating

Erschienen in: Drugs | Ausgabe 3/2009

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Abstract

  • ▴ Oxybutynin inhibits contraction of the detrusor muscle in the overactive bladder by binding to muscarinic M3 receptors and blocking acetylcholinergic activation.
  • ▴ The transdermal oxybutynin system, applied twice weekly, delivers continuous oxybutynin over a 96-hour patch wear period. The transdermal route of administration avoids the extensive first-pass metabolism of oxybutynin to its active metabolite, N- desethyloxybutynin.
  • ▴ In two well designed trials in patients with overactive bladder, transdermal oxybutynin 3.9 mg/day decreased the number of incontinence episodes and increased average voided volume to a significantly greater extent than placebo. Urinary frequency was improved to a significantly greater extent with transdermal oxybutynin than with placebo in one trial but not the other.
  • ▴ There was no significant difference between transdermal oxybutynin and extended-release oral tolterodine for any of these endpoints.
  • ▴ Health-related quality-of-life improvements with transdermal oxybutynin were shown in patients with overactive bladder in the open-label MATRIX trial, as demonstrated by significant improvements in all domains of the King’s Health Questionnaire.
  • ▴ Transdermal oxybutynin is generally well tolerated in patients with overactive bladder. The majority of patients who discontinued transdermal oxybutynin treatment in two pivotal trials did so because of application-site reactions. However, none discontinued treatment because of dry mouth.
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Metadaten
Titel
Transdermal Oxybutynin
verfasst von
Claudine M. Baldwin
Gillian M. Keating
Publikationsdatum
01.02.2009
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 3/2009
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.2165/00003495-200969030-00008

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