Acknowledgements
The authors acknowledge Lisa M. Klumpp, PhD, Cynthia Gobbel, PhD, and Lisa Feder, PhD, from Scientific Connexions (Newtown, PA, USA) for writing assistance funded by AstraZeneca LP, the study sponsor, which designed the study and participated in the management, analysis and interpretation of the data and in the review and approval of the article. The study was supported by AstraZeneca LP, Wilmington, DE, USA.
Dr Tashkin has served as consultant for AstraZeneca, Boehringer-Ingelheim, Dey Laboratories and Schering-Plough; received honoraria from AstraZeneca, Boehringer-Ingelheim and Dey Laboratories; and received or will receive grants from Almirall, AstraZeneca, Boehringer-Ingelheim, Dey Laboratories, GlaxoSmithKline, NIH, Novartis, Pfizer, Sepracor and Forest Laboratories. Dr Rennard has served as a consultant or on the advisory board for Adams, Almirall, Altana, APT, Aradigm, AstraZeneca, Bend, Biolipox, Centocor, Critical Therapeutics, Dey, GlaxoSmithKline, ICOS, Johnson & Johnson, Novartis, Nycomed, Ono Pharma, Perengenix, Pfizer, Pharmaxis, Roche, Sankyo, Sanofi, Schering-Plough and Talecris; has served as a speaker for AstraZeneca, Boehringer-Ingelheim, GlaxoSmithKline, Otsuka and Pfizer; and has received grants from Almirall, Altana, Astellas, AstraZeneca, Biomark, Centocor, GlaxoSmithKline, Mpex, Nabi, Novartis and Pfizer. Ms McElhattan and Dr Goldman are employees of AstraZeneca LP. Dr Ramachandran and Dr Martin hold stock in AstraZeneca LP and are employees of AstraZeneca LP. Dr Silkoff is a former employee of AstraZeneca LP.
Investigator List:
We thank the following investigators for their participation in the study: Bulgaria: Vasil Dimitrov, Sofia; Ognian Georgiev, Sofia; Yavor Ivanov, Pleven; Grozdanka Ivanova, Plovdiv; Krassimira Kissiova, Varna; Rossen Marinov, Sofia; Hristo Metev, Russe; Dencho Osmanliev, Sofia; Dimitar Popov, Sofia; Denmark: John Arnved, Copenhagen; Vibeke Backer, Copenhagen; Asger Dirksen, Hellerup; Flemming Egede, Svendborg; Henriette Enevoldsen, Copenhagen; Niels Frølich, Viborg; Michael Hansen, Frederikssund; Michael Jensen, Skive; Kim Mølenberg, Aalborg; Carl Nielsen, Frederikshavn; Povl Revsbech, Silkeborg; Dan Rost, Christiansfeld; Torben Sørensen, Vaerløse; Germany: Helen Arievich, Berlin; Klaus Colberg, Bad Segeberg; Regina Deckelmann, Leipzig; Jörg Eller, Berlin; Wolfram Feussner, Kassel; Karin Förster, Berlin; Adrian Gillisssen, Leipzig; Ulf Harnest, Munich; Andrea Koch, Cologne; Marc Oliver Kornmann, Mainz; Thea Krecker, Bad Salzungen; Ludger Lindemann, Gelsenkirchen; Anneliese Linnhoff, Berlin; Helgo Magnussen, Grosshansdorf; Petra Mikloweit, Geesthacht; Wolfgang Mitlehner, Berlin; Stephan Molitor, Hanover; Herbert Querfurt, Bochum; Gisela Schirrmeister, Postdam; Sören Schmidtmann, Berlin; Wwinfried Schröder-Babo, Gelnhausen; Wolfgang Schürmann, Marburg; Peter-Michael Stutz, Bonn; Hermann Trauth, Marburg; Bernd-Georg Trümper, Erfurt; Anette Weihrich, Neuruppin; Greece: Konstantionos Gourgoulianus, Larisa; Marianna Kakoura, Thessaloniki; Adonis Rasidakis, Athens; Nicolaos Siafakas, Hraklion-Crete; Lazaros Sichletidis, Thessaloniki; Michael Toumbis, Athens; Hungary: Anna Bartha, Siófok; Márta Bisits, Tatabánya; István Boros, Deszk; György Böszörményi Nagy, Budapest; Mária Csányi, Gyöngyös; Zsuzsanna Cseke, Szombathely; Ilona Dalmadi, Keszthely; Radeczky Éva, Százhalombatta; Eva Farkas, Gödöllö; Katalin Gömöri, Balassagyarmat; Zsuzsa Györi, Érd; László Hajdu, Kiskunhalas; Mária Hegedüs, Salgótarján; Mária Jedlinszki, Szarvas; Teréz Kecskés, Pécs; Gábor Kelen, Füzesabony; Tamás Major, Mosdós; Ida Nagy, Jászberény; Miklós Naményi, Veszprém; Emil Prugberger, Sárvár; Katalin Puha, Györ; Katalin Radich, Budapest; Katalin Rajkay, Cegléd; Mária Schreiner, Pécs; Zsuzsanna Szalai, Mosonmagyaróvár; Gyöngyvér Szalóky, Gyula; Sándor Tehenes, Zalaegerszeg; Iceland: Magni Jónsson, Reykjavík; Andrés Sigvaldason, Reykajvík; Mexico: Eliseo Espinoza, Mexico City; Norma Martínez, Mexico City; Raul Ortiz Peregrina, Guadalajara; Alicia Ramirez Rivera, Monterrey; Enrique Rojas, Mexico City; Romania: Ioana Agache, Brasov; Nicoleta Bisca, Bucharest; Ioan Dorin Petrui, Deva; Traian Mihaescu, Iasi; Angelica Savu, Bucharest; Octavian Verescu, Bucharest; USA: Connie Abarikwu, Phoenix, AZ; Salim Abou-Jaoude, Youngstown, OH; John Adams, Houston, TX; Lawrence Alwine, Downingtown, PA; C. Lynn V Anderson, Bay Pines, FL; Charles Andrews, San Antonio, TX; Raiqua Arastu, San Antonio, TX; William Bailey, Birmingham, AL; Jose Bardelas, High Point, NC; Kendrick Bashor, Mogadore, OK; George Bensch, Stockton, CA; David Bernstein, Cincinnati, OH; Eugene Bleecker, Winston-Salem, NC; Vinko Bogdanic, Waterloo, IA; Joseph Boscia, Gaffney, SC; Sidney Braman, Providence, RI; Wesley Bray, Marietta, GA; Shari Anne Brazinsky, San Diego, CA; Dwayne Brown, Lafayette, LA; Jaine Brownell, Omaha, NE; Timothy Bruya, Spokane, WA; John Burk, Fort Worth, TX; Anthony Cagino, Albany, NY; Brian Cain, Mogadore, OK; Edward Campbell, Provo, UT; Sammy Campbell, Tucson, AZ; Francisco Candal, Slidell, LA; Brian W. Carlin, Pittsburgh, PA; Wissam Chatila, Philadelphia, PA; Jim Christensen, Las Vegas, NV; Dariusz Chrostowski, Ithaca, NY; John Condemi, Rochester, NY; Clinton Corder, Oklahoma City, OK; Arthur Degraff, Hartford, CT; Edward Diamond, Elk Grove Village, IL; Joel Diamond, Pittsburgh, PA; Mark Dransfield, Birmingham, AL; Gustav A. Dubois, Birmingham, AL; Leonard Dunn, Clearwater, FL; Gordon Eck, Elverson, PA; Darlene Elias, La Jolla, CA; Steven Elliott, Evansville, IN; David Erb, Union, SC; Barry Feinstein, Shreveport, LA; Gregory Feldman, Spartanburg, SC; Roan L. Flenniken, Shreveport, LA; Charles Fogarty, Spartanburg, SC; Toby Free, McCook, NE; Eli Freilich, Clearwater, FL; Fred Garfinkel, Tulsa, OK; Sandra Gawchik, Upland, PA; Harry Geisburg, Anderson, SC; William George, Cadillac, MI; Ronald Gilman, East Providence, RI; Joan Gluck, Miami, FL; Daniel Goldberger, Portage, MI; Gary Greenwald, Rancho Mirage, CA; Gary Gross, Dallas, TX; Roger Guthrie, Pismo Beach, CA; James Haden, Fort Worth, TX; Jeffrey Hammersley, Toledo, OH; James Hansbrough, Bowling Green, KY; Duane Harris, Salt Lake City, UT; James Harris, South Bend, IN; David Hassman, Berlin, NJ; Delmer Henninger, Murrieta, CA; Ira Horowitz, Cherry Hill, NJ; Gary Hunt, Blue Ridge, GA; Sean Hurley, Spokane, WA; Thomas Hyers, St. Louis, MO; Thomas Kaelin, Charleston, SC; Richard Kahn, Biddleford, ME; Harold Kaiser, Minneapolis, MN; Jill Karpel, New Hyde Park, NY; F. Adam Kawley, Houston, TX; Edward Kerwin, Minneapolis, MN; W. Ken Kleinsteuber, Louisville, KY; Andras Koser, Greenville, SC; Ritsu Kuno, Richmond, VA; Ware Kuschner, Palo Alto, CA; Mark Kutner, Miami, FL; David Laman, Pittsburgh, PA; Lauro Lapuz, Henderson, NV; Michael Lawrence, Taunton, MA; Dennis Ledford, Tampa, FL; Theodore Lee, Atlanta, GA; Lyndon Mansfield, El Paso, TX; Dennis McCluskey, Mogadore, OK; Arturo Meade, Fort Smith, AR; James Meli, Henderson, NV; Edward Millermaier, Portage, MI; Martin Mollen, Phoenix, AZ; Melvin Morganroth, Portland, OR; Timothy Moriarty, Panama City, FL; James Moy, Chicago, IL; Anjuli Nayak, Normal, IL; Brooke Nevins, Bronxville, NY; Michael Noonan, Portland, OR; Amir Ali Noorani, New Port Richey, FL; Eric Overland, Medford, OR; Parimal Parikh, Kenner, LA; Amit Patel, Riverside, CA; Rafael Perez, Decatur, GA; Stephen Pollard, Louisville, KY; Rana Rab-Hasan, Decatur, GA; Albert Razzetti, DeLand, FL; Frank Reda, Pittsburgh, PA; Emory Robinette, Abingdon, VA; Christine Rohr, Saginaw, MI; Bradley Sakran, O’Fallon, IL; Paul J. Scheinberg, Atlanta, GA; E. Joe Schelbar, Tulsa, OK; Robert Schilz, Cleveland, OH; Nathan Segall, Stockbridge, GA; Pedro Sepulveda, San Antonio, TX; Paul Shapero, Bangor, ME; Amir Sharafkhaneh, Houston, TX; Mandy Shaw, Omaha, NE; Tanna Shaw, Oklahoma City, OK; Mike Shedd, Scottsbluff, NE; T. Shull Lemire, Missoula, MT; Thomas Siler, St. Charles, MO; Wayne Sinclair, Missoula, MT; Deren M. Sinkowitz, Torrance, CA; Emil Skobeloff, Swarthmore, PA; Andrew Slaski, Tucson, AZ; Christopher Smith, Ithaca, NY; Gregory Smith, Sacramento, CA; Philip Snell, Greer, SC; John Southard, Council Bluffs, IA; Michael Spandorfer, Charleston, SC; Sheldon Spector, Los Angeles, CA; Mark Stang, Edina, MN; Ronald Stegemoller, Avon, IN; Clement Strumil, Las Vegas, NV; Patrick Sturm, Beaver, PA; Raul Tamayo, Longwood, FL; George Tannoury, Pahrump, NV; Gary Tarshis, Colorado Springs, CO; Stuart Thorson, Medford, OR; Melvin Tonkon, Santa Ana, CA; Diego Torres, Ormond Beach, FL; Miguel Trevino, Largo, FL; John Updegrove, Corsicana, TX; Robert Venuti, Turnersville, NJ; Thomas Wade, Indianapolis, IN; John Weiler, Iowa City, IA; Jan Westerman, Jasper, AL; Douglas Young, Carmichael, CA.