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Neurocardiogenic Syncope in Children

Current Concepts in Diagnosis and Management

  • Therapy In Practice
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Abstract

A wide variety of pharmacologic agents are currently used for the prevention of recurrent neurocardiogenic syncope in children and adolescents. Significant advances in the understanding of this syncopal disorder have occurred in the past decade, and the list of medications recommended has changed, reflecting the evolving understanding of the pathophysiology and development of agents with enhanced efficacy and fewer adverse effects. Clinicians have few randomized controlled trials available to guide their decisions about treating neurocardiogenic syncope, and even fewer when it comes to medications targeting the pediatric population. At the present time, β-adrenergic receptor blockers, fludrocortisone, and also specific serotonin reuptake inhibitors and midodrine, appear to be favored treatment options. Ideally, specific therapy would be tailored to specific pathophysiologic mechanisms. Unfortunately, at present, specific treatments based on those abnormalities have not been identified.

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Acknowledgements

Professor Massin would like to thank the Belgian National Foundation for Research on Pediatric Cardiology for their financial support of the Division of Pediatric Cardiology. He also gratefully acknowledges the help of Professor Philippe Lepage, Department of Pediatrics, University of Liège, Belgium, for his assistance in reviewing this manuscript.

No sources of funding were used to assist in the preparation of this manuscript. The authors have no conflicts of interest that are directly relevant to the content of this manuscript.

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  1. Division of Pediatric Cardiology, University of Liège at Regional Hospital Centre La Citadelle, Liège, Belgium

    Martial M. Massin

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Correspondence to Martial M. Massin.

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Massin, M.M. Neurocardiogenic Syncope in Children. Pediatr-Drugs 5, 327–334 (2003). https://doi.org/10.2165/00128072-200305050-00005

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