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A Preference Evaluation Study Comparing the Sensory Attributes of Mometasone Furoate and Fluticasone Propionate Nasal Sprays by Patients with Allergic Rhinitis

  • Original Research Article
  • Published:
Treatments in Respiratory Medicine

Abstract

Objective: Data on intranasal corticosteroids suggest that individual product attributes may influence patient preference for therapy in allergic rhinitis. The study objective was to compare product sensory attributes and their impact upon patient preference for scent-free mometasone furoate nasal spray (MFNS) versus fluticasone propionate nasal spray (FPNS) in patients with symptomatic allergic rhinitis.

Methods: In a double-blind, crossover study, 100 patients were randomized to MFNS 200μg followed by FPNS 200μg, or vice versa. Patients rated the study drugs by completing an individual product sensory attributes questionnaire at the end of each period of drug administration. An overall sensory preference questionnaire was completed following crossover.

Results: A significantly greater number of patients preferred MFNS to FPNS (p < 0.05). MFNS was superior for a number of individual sensory attributes based on mean patient ratings: significantly fewer patients perceived scent/odor (immediately and 2 minutes after drug administration; p < 0.001), taste (immediately after drug administration; p = 0.002), and after-taste (2 minutes after drug administration; p = 0.007) with MFNS compared with FPNS. Similarly, product sensory attribute preference data demonstrated that twice the number of patients preferred MFNS to FPNS for scent/odor (p = 0.0005), immediate taste (p = 0.005), and after-taste (p = 0.005). Fifty-four percent of patients said they would choose a prescription for MFNS compared with 33% for FPNS (p = 0.03). In addition, 47% of patients would be more likely to comply (use daily as directed) with MFNS compared with 25% with FPNS (p = 0.03).

Conclusion: Several individual sensory attributes of MFNS were rated significantly superior to FPNS. Overall, based on the tested sensory attributes, patients preferred MFNS to FPNS therapy for the treatment of allergic rhinitis.

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Notes

  1. 1 The use of trade names is for product identification purposes only and does not imply endorsement.

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Acknowledgments

This study was supported by the Integrated Therapeutics Group, Inc. (a subsidiary of the Schering-Plough Corporation). Editorial assistance was provided by Thomson Gardiner-Caldwell London.

The author(s) certify that they have no affiliation with, or financial involvement in, any organization or entity with a direct financial interest in the subject matter or materials discussed in this manuscript (e.g. employment, consultancies, stock ownership, honoraria).

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Authors and Affiliations

  1. Allergy and Asthma Medical Group & Research Center, California, 9610 Granite Ridge, Drive, Suite B, San Diego, 92123, USA

    Eli O. Meltzer

  2. Allergy and Asthma Center of NCPA, North Carolina, USA

    Jose Bardelas

  3. Allergy and Asthma Associates Research Center, San Jose, California, USA

    Alan Goldsobel

  4. Allergy and Asthma Specialists PA, Minneapolis, Minnesota, USA

    Harold Kaiser

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  1. Eli O. Meltzer
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  2. Jose Bardelas
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  3. Alan Goldsobel
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  4. Harold Kaiser
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Meltzer, E.O., Bardelas, J., Goldsobel, A. et al. A Preference Evaluation Study Comparing the Sensory Attributes of Mometasone Furoate and Fluticasone Propionate Nasal Sprays by Patients with Allergic Rhinitis. Treat Respir Med 4, 289–296 (2005). https://doi.org/10.2165/00151829-200504040-00007

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