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Erschienen in: Drugs 8/2011

01.05.2011 | Review Article

Pharmacotherapeutic Management of Locally Advanced Prostate Cancer

Current Status

verfasst von: Dr Jarad M. Martin, Stephane Supiot, Dominik R. Berthold

Erschienen in: Drugs | Ausgabe 8/2011

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Abstract

Locally advanced prostate cancer (LAPC) is a heterogeneous entity usually embracing T3-4 and/or pelvic lymph-node-positive disease in the absence of established metastases. Outcomes for LAPC with single therapies have traditionally been poor, leading to the investigation of adjuvant therapies. Prostate cancer is a hormonally sensitive tumour, which usually responds to pharmacological manipulation of the androgen receptor or its testosterone-related ligands. As such, androgen deprivation therapy (ADT) has become an important adjuvant strategy for the treatment of LAPC, particularly for patients managed primarily with radiotherapy. Such results have generally not been replicated in surgical patients. With increased use of ADT has come improved awareness of the numerous toxicities associated with long-term use of these agents, as well as the development of strategies for minimizing ADT exposure and actively managing adverse effects. Several trials are exploring agents to enhance radiation cell sensitivity as well as the application of adjuvant docetaxel, an agent with proven efficacy in the metastatic, castrate-resistant setting. The recent work showing activity of cabazitaxel, sipuleucel-T and abiraterone for castrate-resistant disease in the post-docetaxel setting will see these agents investigated in conjunction with definitive surgery and radiotherapy.
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Metadaten
Titel
Pharmacotherapeutic Management of Locally Advanced Prostate Cancer
Current Status
verfasst von
Dr Jarad M. Martin
Stephane Supiot
Dominik R. Berthold
Publikationsdatum
01.05.2011
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 8/2011
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.2165/11591500-000000000-00000

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