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Erschienen in: PharmacoEconomics 8/2011

01.08.2011 | Current Opinion

Challenges in Health State Valuation in Paediatric Economic Evaluation

Are QALYs Contraindicated?

verfasst von: Dr Wendy J. Ungar

Erschienen in: PharmacoEconomics | Ausgabe 8/2011

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Abstract

With the growth in the use of health economic evaluation to inform healthcare resource allocation decisions, the challenges in applying standard methods to child health have become apparent.Aunique limitation is the paucity of childspecific preference-based measures. A single, valid, preference-based measure of utility that can be used in children of all ages does not exist. Thus, the ability to derive a QALY for use in cost-utility analysis (CUA) is compromised. This paper presents and discusses existing and novel options for deriving utilities for paediatric health states for use in CUAs.
While a direct elicitation may be preferred, a child’s ability to complete a standard gamble or time trade-off task is hampered by cognitive and age limitations. The abstract notions contained in indirect instruments such as the EQ-5D and Health Utilities Index may also pose challenges for young children. Novel approaches to overcome these challenges include the development of age-appropriate instruments such as the EQ-5D-Y, the development of new child-specific utility instruments such as the Child Health Utility-9D and the re-calibration of existing adult instruments to derive preference weights for health states from children themselves. For children aged <6 years, researchers have little choice but to use a proxy reporter such as parents. While parents may be reliable reporters for physical activity limitations and externally manifest symptoms, their ability to accurately report on subjective outcomes such as emotion is questionable. Catalogues of utility weights for a range of conditions are increasingly becoming available but retain many of the same limitations as valuing health states from children or from proxies.
Given the dynamic relationship in quality of life (QOL) between family members when a child is ill, it seems appropriate to consider a family perspective rather than an individual perspective in child health state valuation. In a collective approach, health state utilities derived from multiple family members may be combined mathematically. Alternatively, in a unitary approach, a single utility estimate may be determined to represent the familys perspective. This may include deriving utilities through parent-child dyad estimation or by using a household model that combines the utility weights of the patient and family members, incorporating reciprocal QOL effects.
While these various approaches to child health state valuation represent novel research developments, the measurement challenges and threats to validity persist. Given the importance of non-health benefits to child health, especially in the domains of education and public policy, it may be worthwhile to consider an approach that allows incorporation of externalities to produce a cost-benefit analysis. The use of discrete-choice methods to assess willingness to pay for novel child health interventions holds promise as a means to produce meaningful economic evidence.
Regardless of the approach taken, the highest degree of methodological rigour is essential. The increasing attention being paid by health economic researchers to the measurement challenges of paediatric health state valuation can only increase the value of child health economic evidence for decision making.
Literatur
1.
Zurück zum Zitat Griebsch I, Coast J, Brown J. Quality-adjusted life-years lack quality in pediatric care: a critical review of published costutility studies in child health. Pediatrics 2005; 115 (5): 2004–127CrossRef Griebsch I, Coast J, Brown J. Quality-adjusted life-years lack quality in pediatric care: a critical review of published costutility studies in child health. Pediatrics 2005; 115 (5): 2004–127CrossRef
2.
Zurück zum Zitat Tilford JM. Cost-effectiveness analysis and emergency medical services for children: issues and applications. Ambul Pediatr 2002; 2 (4 Suppl.): 330–6PubMedCrossRef Tilford JM. Cost-effectiveness analysis and emergency medical services for children: issues and applications. Ambul Pediatr 2002; 2 (4 Suppl.): 330–6PubMedCrossRef
3.
Zurück zum Zitat Ungar WJ. Paediatric health economic evaluations: a world view. Healthc Q 2006; 10 (1): 134–40, 42–5 Ungar WJ. Paediatric health economic evaluations: a world view. Healthc Q 2006; 10 (1): 134–40, 42–5
4.
Zurück zum Zitat Keren R, Pati S, Feudtner C. The generation gap: differences between children and adults pertinent to economic evaluations of health interventions. Pharmacoeconomics 2004; 22 (2): 71–81PubMedCrossRef Keren R, Pati S, Feudtner C. The generation gap: differences between children and adults pertinent to economic evaluations of health interventions. Pharmacoeconomics 2004; 22 (2): 71–81PubMedCrossRef
5.
Zurück zum Zitat Ungar WJ, Gerber A. The uniqueness of child health and challenges to measuring costs and consequences. In:Ungar WJ, editor. Economic evaluation in child health. Oxford: Oxford University Press, 2010: 3–32 Ungar WJ, Gerber A. The uniqueness of child health and challenges to measuring costs and consequences. In:Ungar WJ, editor. Economic evaluation in child health. Oxford: Oxford University Press, 2010: 3–32
6.
Zurück zum Zitat Ungar WJ, Santos MT. The quality of pediatric health economic evaluations. Int J Technol Assess Health Care 2005; 21 (2): 203–10PubMed Ungar WJ, Santos MT. The quality of pediatric health economic evaluations. Int J Technol Assess Health Care 2005; 21 (2): 203–10PubMed
7.
Zurück zum Zitat Walker D, Fox-Rushby JA. Economic evaluation of communicable disease interventions in developing countries: a critical review of the published literature. Health Econ 2000; 9 (8): 681–98PubMedCrossRef Walker D, Fox-Rushby JA. Economic evaluation of communicable disease interventions in developing countries: a critical review of the published literature. Health Econ 2000; 9 (8): 681–98PubMedCrossRef
8.
Zurück zum Zitat Guidelines for the economic evaluation of health technologies: Canada. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health, 2006 Guidelines for the economic evaluation of health technologies: Canada. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health, 2006
9.
Zurück zum Zitat National Institute for Health and Clinical Excellence. Guide to the methods of technology appraisal. London: NICE, 2008. Report no.: N1618 National Institute for Health and Clinical Excellence. Guide to the methods of technology appraisal. London: NICE, 2008. Report no.: N1618
10.
Zurück zum Zitat Prosser LA, Hammitt JK, Keren R. Measuring health preferences for use in cost-utility and cost-benefit analyses of interventions in children: theoretical and methodological considerations. Pharmacoeconomics 2007; 25 (9): 713–26PubMedCrossRef Prosser LA, Hammitt JK, Keren R. Measuring health preferences for use in cost-utility and cost-benefit analyses of interventions in children: theoretical and methodological considerations. Pharmacoeconomics 2007; 25 (9): 713–26PubMedCrossRef
11.
Zurück zum Zitat Drummond MF, Sculpher MJ, Torrance GW, et al. Methods for the economic evaluation of health care programmes. 3rd ed. Oxford: Oxford University Press, 2005 Drummond MF, Sculpher MJ, Torrance GW, et al. Methods for the economic evaluation of health care programmes. 3rd ed. Oxford: Oxford University Press, 2005
12.
Zurück zum Zitat Horsman J, Furlong W, Feeny D, et al. The health utilities index (HUI): concepts, measurement properties and applications. Health Qual Life Outcomes 2003 Oct 16; 1: 54PubMedCrossRef Horsman J, Furlong W, Feeny D, et al. The health utilities index (HUI): concepts, measurement properties and applications. Health Qual Life Outcomes 2003 Oct 16; 1: 54PubMedCrossRef
13.
Zurück zum Zitat Petrou S. Methodological issues raised by preference-based approaches to measuring the health status of children. Health Econ 2003; 12 (8): 697–702PubMedCrossRef Petrou S. Methodological issues raised by preference-based approaches to measuring the health status of children. Health Econ 2003; 12 (8): 697–702PubMedCrossRef
14.
Zurück zum Zitat Prosser LA. Current challenges and future research in measuring preferences for pediatric health outcomes. J Pediatr 2009 Jul; 155 (1): 7–9PubMedCrossRef Prosser LA. Current challenges and future research in measuring preferences for pediatric health outcomes. J Pediatr 2009 Jul; 155 (1): 7–9PubMedCrossRef
15.
Zurück zum Zitat Ratcliffe J, Couzner L, Flynn T, et al. Valuing child health utility 9D health states with a young adolescent sample: a feasibility study to compare best-worst scaling, discretechoice experiment, standard gamble and time trade-off methods. Appl Health Econ Health Policy 2011; 9 (1): 15–27PubMedCrossRef Ratcliffe J, Couzner L, Flynn T, et al. Valuing child health utility 9D health states with a young adolescent sample: a feasibility study to compare best-worst scaling, discretechoice experiment, standard gamble and time trade-off methods. Appl Health Econ Health Policy 2011; 9 (1): 15–27PubMedCrossRef
16.
Zurück zum Zitat Stevens KJ. Working with children to develop dimensions for a preference-based, generic, pediatric health-related quality-of-life measure. Qual Health Res 2010; 20: 340–51PubMedCrossRef Stevens KJ. Working with children to develop dimensions for a preference-based, generic, pediatric health-related quality-of-life measure. Qual Health Res 2010; 20: 340–51PubMedCrossRef
17.
Zurück zum Zitat Sung L, Petrou S, Ungar WJ. Measurement of health utilities in children. In: Ungar WJ, editor. Economic evaluation in child health. Oxford: Oxford University Press, 2010 Sung L, Petrou S, Ungar WJ. Measurement of health utilities in children. In: Ungar WJ, editor. Economic evaluation in child health. Oxford: Oxford University Press, 2010
18.
Zurück zum Zitat Von Neumann J, Morgenstern O. Theory of games and economic behavior. 3rd ed. New York: Wiley, 1953 Von Neumann J, Morgenstern O. Theory of games and economic behavior. 3rd ed. New York: Wiley, 1953
19.
Zurück zum Zitat Gold MR, Siegel JE, Russell LB, et al., editors. Cost-effectiveness in health and medicine. New York: 6Oxford University Press, 1996 Gold MR, Siegel JE, Russell LB, et al., editors. Cost-effectiveness in health and medicine. New York: 6Oxford University Press, 1996
20.
Zurück zum Zitat Torrance GW. Utility measurement in healthcare: the things I never got to. Pharmacoeconomics 2006; 24 (11): 1069–78PubMedCrossRef Torrance GW. Utility measurement in healthcare: the things I never got to. Pharmacoeconomics 2006; 24 (11): 1069–78PubMedCrossRef
22.
Zurück zum Zitat Ravens-Sieberer U, Wille N, Badia X, et al. Feasibility, reliability, and validity of the EQ-5D-Y: results from a multinational study. Qual Life Res 2010; 19 (6): 887–97PubMedCrossRef Ravens-Sieberer U, Wille N, Badia X, et al. Feasibility, reliability, and validity of the EQ-5D-Y: results from a multinational study. Qual Life Res 2010; 19 (6): 887–97PubMedCrossRef
23.
Zurück zum Zitat Wille N, Badia X, Bonsel G, et al. Development of the EQ-5D-Y: a child-friendly version of the EQ-5D. Qual Life Res 2010 Aug; 19 (6): 875–86PubMedCrossRef Wille N, Badia X, Bonsel G, et al. Development of the EQ-5D-Y: a child-friendly version of the EQ-5D. Qual Life Res 2010 Aug; 19 (6): 875–86PubMedCrossRef
24.
Zurück zum Zitat Szilagyi PG, Schor EL. The health of children. Health Serv Res 1998; 33 (4): 1001–39PubMed Szilagyi PG, Schor EL. The health of children. Health Serv Res 1998; 33 (4): 1001–39PubMed
25.
Zurück zum Zitat Matza LS, Swensen AR, Flood EM, et al. Assessment of health-related quality of life in children: a review of conceptual, methodological, and regulatory issues. Value Health 2004 Jan-Feb; 7 (1): 79–92PubMedCrossRef Matza LS, Swensen AR, Flood EM, et al. Assessment of health-related quality of life in children: a review of conceptual, methodological, and regulatory issues. Value Health 2004 Jan-Feb; 7 (1): 79–92PubMedCrossRef
26.
Zurück zum Zitat De Civita M, Regier D, Alamgir AH, et al. Evaluating health-related quality-of-life studies in paediatric populations: some conceptual, methodological and developmental considerations and recent applications. Pharmacoeconomics 2005; 23 (7): 659–85PubMedCrossRef De Civita M, Regier D, Alamgir AH, et al. Evaluating health-related quality-of-life studies in paediatric populations: some conceptual, methodological and developmental considerations and recent applications. Pharmacoeconomics 2005; 23 (7): 659–85PubMedCrossRef
27.
Zurück zum Zitat Christakis DA, Johnston BD, Connell FA. Methodologic issues in pediatric outcomes research. Ambul Pediatr 2001; 1 (1): 59–62PubMedCrossRef Christakis DA, Johnston BD, Connell FA. Methodologic issues in pediatric outcomes research. Ambul Pediatr 2001; 1 (1): 59–62PubMedCrossRef
28.
Zurück zum Zitat Stevens K. Developing a descriptive system for a new preference-based measure of health-related quality of life for children. Qual Health Res 2009; 18 (8): 1105–13 Stevens K. Developing a descriptive system for a new preference-based measure of health-related quality of life for children. Qual Health Res 2009; 18 (8): 1105–13
29.
Zurück zum Zitat Stevens K. Assessing the performance of a new generic measure of health-related quality of life for children and refining it for use in health state valuation. Appl Health Econ Health Policy 2011; 9 (3): 157–69PubMedCrossRef Stevens K. Assessing the performance of a new generic measure of health-related quality of life for children and refining it for use in health state valuation. Appl Health Econ Health Policy 2011; 9 (3): 157–69PubMedCrossRef
30.
Zurück zum Zitat Stevens KJ. Valuation of the Child Health Utility Index 9D (CHU9D). Sheffield: The University of Sheffield, 2010 Stevens KJ. Valuation of the Child Health Utility Index 9D (CHU9D). Sheffield: The University of Sheffield, 2010
31.
Zurück zum Zitat Moodie M, Richardson J, Rankin B, et al. Predicting time trade-off health state valuations of adolescents in four Pacific countries using the Assessment of Quality-of-Life (AQoL-6D) instrument. Value Health 2010; 13 (8): 1014–27PubMedCrossRef Moodie M, Richardson J, Rankin B, et al. Predicting time trade-off health state valuations of adolescents in four Pacific countries using the Assessment of Quality-of-Life (AQoL-6D) instrument. Value Health 2010; 13 (8): 1014–27PubMedCrossRef
32.
Zurück zum Zitat Lewis PA, Charny M. Which of two individuals do you treat when only their ages are different and you can’t treat both? J Medical Ethics 1989; 15 (1): 28–34CrossRef Lewis PA, Charny M. Which of two individuals do you treat when only their ages are different and you can’t treat both? J Medical Ethics 1989; 15 (1): 28–34CrossRef
33.
Zurück zum Zitat Conner-Spady B, Suarez-Almazor ME. Variation in the estimation of quality-adjusted life-years by different preferencebased instruments. Med Care 2003 Jul; 41 (7): 791–801PubMedCrossRef Conner-Spady B, Suarez-Almazor ME. Variation in the estimation of quality-adjusted life-years by different preferencebased instruments. Med Care 2003 Jul; 41 (7): 791–801PubMedCrossRef
34.
Zurück zum Zitat Feeny D, Wu L, Eng K. Comparing short form 6D, standard gamble, and Health Utilities Index Mark 2 and Mark 3 utility scores: results from total hip arthroplasty patients. Qual Life Res 2004 Dec; 13 (10): 1659–70PubMedCrossRef Feeny D, Wu L, Eng K. Comparing short form 6D, standard gamble, and Health Utilities Index Mark 2 and Mark 3 utility scores: results from total hip arthroplasty patients. Qual Life Res 2004 Dec; 13 (10): 1659–70PubMedCrossRef
35.
Zurück zum Zitat Kopec JA, Willison KD. A comparative review of four preference-weighted measures of health-related quality of life. J Clin Epidemiol 2003 Apr; 56 (4): 317–25PubMedCrossRef Kopec JA, Willison KD. A comparative review of four preference-weighted measures of health-related quality of life. J Clin Epidemiol 2003 Apr; 56 (4): 317–25PubMedCrossRef
36.
Zurück zum Zitat Marra CA, Esdaile JM, Guh D, et al. A comparison of four indirect methods of assessing utility values in rheumatoid arthritis. Med Care 2004 Nov; 42 (11): 1125–31PubMedCrossRef Marra CA, Esdaile JM, Guh D, et al. A comparison of four indirect methods of assessing utility values in rheumatoid arthritis. Med Care 2004 Nov; 42 (11): 1125–31PubMedCrossRef
37.
Zurück zum Zitat Wee H-L, Machin D, Loke W-C, et al. Assessing differences in utility scores: a comparison of four widely used preferencebased instruments. Value Health 2007 Jul-Aug; 10 (4): 256–65PubMedCrossRef Wee H-L, Machin D, Loke W-C, et al. Assessing differences in utility scores: a comparison of four widely used preferencebased instruments. Value Health 2007 Jul-Aug; 10 (4): 256–65PubMedCrossRef
38.
Zurück zum Zitat Oostenbrink R, A Moll HA, Essink-Bot M-L. The EQ-5D and the Health Utilities Index for permanent sequelae after meningitis: a head-to-head comparison. J Clin Epidemiol 2002; 55 (8): 791–9PubMedCrossRef Oostenbrink R, A Moll HA, Essink-Bot M-L. The EQ-5D and the Health Utilities Index for permanent sequelae after meningitis: a head-to-head comparison. J Clin Epidemiol 2002; 55 (8): 791–9PubMedCrossRef
39.
Zurück zum Zitat Smith-Olinde L, Grosse SD, Olinde F, et al. Health state preference scores for children with permanent childhood hearing loss: a comparative analysis of the QWB and HUI3. Qual Life Res 2008; 17 (6): 943–53PubMedCrossRef Smith-Olinde L, Grosse SD, Olinde F, et al. Health state preference scores for children with permanent childhood hearing loss: a comparative analysis of the QWB and HUI3. Qual Life Res 2008; 17 (6): 943–53PubMedCrossRef
40.
Zurück zum Zitat Jacobson AM, Fried K. Conceptual issues in developing quality of life assessments for children: illustrations from studies of insulin-dependent diabetes mellitus. In: Drotar D, editor. Measuring health-related quality of life in children and adolescents. Mahwah (NJ): Lawrence Erlbaum Associates Publishers, 1998: 131–50 Jacobson AM, Fried K. Conceptual issues in developing quality of life assessments for children: illustrations from studies of insulin-dependent diabetes mellitus. In: Drotar D, editor. Measuring health-related quality of life in children and adolescents. Mahwah (NJ): Lawrence Erlbaum Associates Publishers, 1998: 131–50
41.
Zurück zum Zitat Eiser C, Morse R. Quality-of-life measures in chronic diseases of childhood. Health Technol Assess 2001; 5 (4): 1–156PubMed Eiser C, Morse R. Quality-of-life measures in chronic diseases of childhood. Health Technol Assess 2001; 5 (4): 1–156PubMed
42.
Zurück zum Zitat Kashani JH, Orvaschel H, Burk JP, et al. Informant variance: the issue of parent-child disagreement. J Am Acad Child Psychiatry 1985; 24 (4): 437–41PubMedCrossRef Kashani JH, Orvaschel H, Burk JP, et al. Informant variance: the issue of parent-child disagreement. J Am Acad Child Psychiatry 1985; 24 (4): 437–41PubMedCrossRef
43.
Zurück zum Zitat Kazdin AE, French NH, Unis AS, et al. Assessment of childhood depression: correspondence of child and parent ratings. J Am Acad Child Psychiatry 1983; 22 (2): 157–64PubMedCrossRef Kazdin AE, French NH, Unis AS, et al. Assessment of childhood depression: correspondence of child and parent ratings. J Am Acad Child Psychiatry 1983; 22 (2): 157–64PubMedCrossRef
44.
Zurück zum Zitat Brunner HI, Maker D, Grundland B, et al. Preference-based measurement of health-related quality of life (HRQL) in children with chronic musculoskeletal disorders (MSKDs). Med Decis Making 2003 Jul-Aug; 23 (4): 314–22PubMedCrossRef Brunner HI, Maker D, Grundland B, et al. Preference-based measurement of health-related quality of life (HRQL) in children with chronic musculoskeletal disorders (MSKDs). Med Decis Making 2003 Jul-Aug; 23 (4): 314–22PubMedCrossRef
45.
Zurück zum Zitat Saigal S, Rosenbaum PL, Feeny D, et al. Parental perspectives of the health status and health-related quality of life of teen-aged children who were extremely low birth weight and term controls. Pediatrics 2000; 105 (3): 569–74PubMedCrossRef Saigal S, Rosenbaum PL, Feeny D, et al. Parental perspectives of the health status and health-related quality of life of teen-aged children who were extremely low birth weight and term controls. Pediatrics 2000; 105 (3): 569–74PubMedCrossRef
46.
Zurück zum Zitat Sung L, Young NL, Greenberg ML, et al. Health-related quality of life (HRQL) scores reported fromparents and their children with chronic illness differed depending on utility elicitation method. J Clin Epidemiol 2004 Nov; 57 (11): 1161–6PubMedCrossRef Sung L, Young NL, Greenberg ML, et al. Health-related quality of life (HRQL) scores reported fromparents and their children with chronic illness differed depending on utility elicitation method. J Clin Epidemiol 2004 Nov; 57 (11): 1161–6PubMedCrossRef
47.
Zurück zum Zitat Brouwer WBF, van Exel NJA, van Gorp B, et al. The CarerQol: a new instrument to measure care-related quality of life of informal caregivers for use in economic evaluations. Qual Life Res 2006; 15: 1005–21PubMedCrossRef Brouwer WBF, van Exel NJA, van Gorp B, et al. The CarerQol: a new instrument to measure care-related quality of life of informal caregivers for use in economic evaluations. Qual Life Res 2006; 15: 1005–21PubMedCrossRef
48.
Zurück zum Zitat Juniper EF, Guyatt GH, Feeny DH, et al. Measuring quality of life in the parents of children with asthma. Qual Life Res 1996; 5: 27–34PubMedCrossRef Juniper EF, Guyatt GH, Feeny DH, et al. Measuring quality of life in the parents of children with asthma. Qual Life Res 1996; 5: 27–34PubMedCrossRef
49.
Zurück zum Zitat Carroll AE, Downs SM. Improving decision analyses: parent preferences (utility values) for pediatric health outcomes. J Pediatr 2009 Jul; 155 (1): 21–5, 5 e1-5PubMedCrossRef Carroll AE, Downs SM. Improving decision analyses: parent preferences (utility values) for pediatric health outcomes. J Pediatr 2009 Jul; 155 (1): 21–5, 5 e1-5PubMedCrossRef
50.
Zurück zum Zitat Petrou S, Kupek E. Estimating preference-based health utilities indexmark 3 utility scores for childhood conditions in England and Scotland. Med Decis Making 2009 May-Jun; 29 (3): 291–303PubMedCrossRef Petrou S, Kupek E. Estimating preference-based health utilities indexmark 3 utility scores for childhood conditions in England and Scotland. Med Decis Making 2009 May-Jun; 29 (3): 291–303PubMedCrossRef
51.
Zurück zum Zitat Forrest CB, Riley AW, Vivier PM, et al. Predictors of children’s healthcare use: the value of child versus parental perspectives on healthcare needs. Med Care 2004; 42 (3): 232–8PubMedCrossRef Forrest CB, Riley AW, Vivier PM, et al. Predictors of children’s healthcare use: the value of child versus parental perspectives on healthcare needs. Med Care 2004; 42 (3): 232–8PubMedCrossRef
52.
Zurück zum Zitat Landgraf JM, Abetz LN. Measuring health outcomes in pediatric populations: issues in psychometrics and application. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. 2nd ed. Philadelphia (PA): Lippincott-Raven Publishers, 1996: 793–802 Landgraf JM, Abetz LN. Measuring health outcomes in pediatric populations: issues in psychometrics and application. In: Spilker B, editor. Quality of life and pharmacoeconomics in clinical trials. 2nd ed. Philadelphia (PA): Lippincott-Raven Publishers, 1996: 793–802
53.
Zurück zum Zitat Olson LM, Asmussen L. Current methods in measuring health-related quality of life in children with asthma. In: Weiss KB, Buist AS, Sullivan SD, editors. Asthma’s impact on society, the social and economic burden. New York: Marcel Dekker Inc, 2000: 99–126 Olson LM, Asmussen L. Current methods in measuring health-related quality of life in children with asthma. In: Weiss KB, Buist AS, Sullivan SD, editors. Asthma’s impact on society, the social and economic burden. New York: Marcel Dekker Inc, 2000: 99–126
54.
Zurück zum Zitat Case A, Paxson C. Mothers and others: who invests in children’s health? J Health Econ 2000; 20: 301–28CrossRef Case A, Paxson C. Mothers and others: who invests in children’s health? J Health Econ 2000; 20: 301–28CrossRef
55.
Zurück zum Zitat Chen AY, Escarce JJ. Family structure and the treatment of childhood asthma. Med Care 2008; 46 (2): 174–84PubMedCrossRef Chen AY, Escarce JJ. Family structure and the treatment of childhood asthma. Med Care 2008; 46 (2): 174–84PubMedCrossRef
56.
Zurück zum Zitat Jacobson L. The family as producer of health: an extended Grossman model. J Health Econ 2000; 19: 611–37PubMedCrossRef Jacobson L. The family as producer of health: an extended Grossman model. J Health Econ 2000; 19: 611–37PubMedCrossRef
57.
Zurück zum Zitat Anderson D, Dumont S, Jacobs P, et al. The personal costs of caring for a child with a disability: a review of the literature. Public Health Rep 2007; 122: 3–16PubMed Anderson D, Dumont S, Jacobs P, et al. The personal costs of caring for a child with a disability: a review of the literature. Public Health Rep 2007; 122: 3–16PubMed
58.
Zurück zum Zitat Curtis LJ, Dooley MD, Lipman EL, et al. The role of permanent income and family structure in the determination of child health in Canada. Health Econ 2001; 10 (4): 287–302PubMedCrossRef Curtis LJ, Dooley MD, Lipman EL, et al. The role of permanent income and family structure in the determination of child health in Canada. Health Econ 2001; 10 (4): 287–302PubMedCrossRef
59.
Zurück zum Zitat Dickie M, Gerking S. Valuing children’s health: parental perspectives. Economic valuation of environmental health risks to children. Paris: Organisation for Economic Cooperation and Development (OECD), 2006: 121–58 Dickie M, Gerking S. Valuing children’s health: parental perspectives. Economic valuation of environmental health risks to children. Paris: Organisation for Economic Cooperation and Development (OECD), 2006: 121–58
60.
Zurück zum Zitat Fu AZ. On the issue of utility multiplication: predicting joint health-states utility. ISPOR Connections 2009; 15 (5): 4–5 Fu AZ. On the issue of utility multiplication: predicting joint health-states utility. ISPOR Connections 2009; 15 (5): 4–5
61.
Zurück zum Zitat Ungar WJ, Mirabelli C, Cousins M, et al. A qualitative analysis of a dyad approach to health-related quality of life measurement in children with asthma. Soc Sci Med 2006 Nov; 63 (9): 2354–66PubMedCrossRef Ungar WJ, Mirabelli C, Cousins M, et al. A qualitative analysis of a dyad approach to health-related quality of life measurement in children with asthma. Soc Sci Med 2006 Nov; 63 (9): 2354–66PubMedCrossRef
62.
Zurück zum Zitat Ungar WJ, Boydell K, Dell S, et al. The validity and reliability of a parent-child dyad approach to utility and quality of-life assessment in children [abstract no. PM3]. Value Health 2008; 11 (3): A14CrossRef Ungar WJ, Boydell K, Dell S, et al. The validity and reliability of a parent-child dyad approach to utility and quality of-life assessment in children [abstract no. PM3]. Value Health 2008; 11 (3): A14CrossRef
63.
Zurück zum Zitat Davidson-Grimwood SR, Snelgrove D, Ungar WJ. The development of an interview guide for use in dyad childparent health related quality of life assessment. PRO Newsletter 2006; 37: 12–4 Davidson-Grimwood SR, Snelgrove D, Ungar WJ. The development of an interview guide for use in dyad childparent health related quality of life assessment. PRO Newsletter 2006; 37: 12–4
64.
Zurück zum Zitat Basu A, Meltzer D. Implications of spillover effects within the family for medical cost-effectiveness analysis. J Health Econ 2005; 24: 751–73PubMedCrossRef Basu A, Meltzer D. Implications of spillover effects within the family for medical cost-effectiveness analysis. J Health Econ 2005; 24: 751–73PubMedCrossRef
65.
Zurück zum Zitat Payakachat N, Tilford JM, Pyne JM, et al. Using generic measures to obtain health utility in child health: a case study evaluating health of children with autism spectrum disorders [abstract no. IP6]. International Society of Pharmacoeconomics and Outcomes Research 13th Annual European Congress; 2010 Nov 6–9; Prague Payakachat N, Tilford JM, Pyne JM, et al. Using generic measures to obtain health utility in child health: a case study evaluating health of children with autism spectrum disorders [abstract no. IP6]. International Society of Pharmacoeconomics and Outcomes Research 13th Annual European Congress; 2010 Nov 6–9; Prague
66.
Zurück zum Zitat Prosser LA, Ray GT, O’Brien M, et al. Preferences and willingness to pay for health states prevented by pneumococcal conjugate vaccine. Pediatrics 2004 Feb; 113 (2): 283–90PubMedCrossRef Prosser LA, Ray GT, O’Brien M, et al. Preferences and willingness to pay for health states prevented by pneumococcal conjugate vaccine. Pediatrics 2004 Feb; 113 (2): 283–90PubMedCrossRef
67.
Zurück zum Zitat Basu A, Dale W, Elstein A, et al. A time tradeoff method for eliciting partners quality of life due to patient’s health states in prostate cancer. Med Decis Making 2010; 30: 355–65PubMedCrossRef Basu A, Dale W, Elstein A, et al. A time tradeoff method for eliciting partners quality of life due to patient’s health states in prostate cancer. Med Decis Making 2010; 30: 355–65PubMedCrossRef
68.
Zurück zum Zitat Annett RD. Assessment of health status and quality of life outcomes for children with asthma. J Allergy Clin Immunol 2001; 107: S473–81CrossRef Annett RD. Assessment of health status and quality of life outcomes for children with asthma. J Allergy Clin Immunol 2001; 107: S473–81CrossRef
69.
Zurück zum Zitat Krupnick AJ. Valuing health outcomes: policy choices and technical issues. Washington, DC: Resources for the Future, 2004 Mar Krupnick AJ. Valuing health outcomes: policy choices and technical issues. Washington, DC: Resources for the Future, 2004 Mar
70.
Zurück zum Zitat Liu J-T, Hammitt JK, Wang J-D, et al. Mother’s willingness to pay for her own and her child’s health: a contingent valuation study in Taiwan. Health Econ 2000; 9: 31–326CrossRef Liu J-T, Hammitt JK, Wang J-D, et al. Mother’s willingness to pay for her own and her child’s health: a contingent valuation study in Taiwan. Health Econ 2000; 9: 31–326CrossRef
71.
Zurück zum Zitat Agee MD, Crocker TD. Transferring measures of adult health benefits to children: economic valuation of environmental health risks to children. Paris: Organisation for Economic Co-operation and Development (OECD), 2006: 159–85 Agee MD, Crocker TD. Transferring measures of adult health benefits to children: economic valuation of environmental health risks to children. Paris: Organisation for Economic Co-operation and Development (OECD), 2006: 159–85
72.
Zurück zum Zitat Hensher DA, Rose JM, Greene WH. Applied choice analysis: a primer. Cambridge: Cambridge University Press, 2005CrossRef Hensher DA, Rose JM, Greene WH. Applied choice analysis: a primer. Cambridge: Cambridge University Press, 2005CrossRef
73.
Zurück zum Zitat Train KE. Discrete choice methods with simulation. Cambridge: Cambridge University Press, 2003 Train KE. Discrete choice methods with simulation. Cambridge: Cambridge University Press, 2003
74.
Zurück zum Zitat Flynn TN. Using conjoint analysis and choice experiments to estimate QALY values: issues to consider. Pharmacoeconomics 2010; 28 (9): 711–22PubMedCrossRef Flynn TN. Using conjoint analysis and choice experiments to estimate QALY values: issues to consider. Pharmacoeconomics 2010; 28 (9): 711–22PubMedCrossRef
76.
Zurück zum Zitat Wolfe I, Cass H, Thompson MJ, et al. Improving child health services in the UK: insights from Europe and their implications for the NHS reforms. BMJ. Epub 2011 Mar 8 Wolfe I, Cass H, Thompson MJ, et al. Improving child health services in the UK: insights from Europe and their implications for the NHS reforms. BMJ. Epub 2011 Mar 8
Metadaten
Titel
Challenges in Health State Valuation in Paediatric Economic Evaluation
Are QALYs Contraindicated?
verfasst von
Dr Wendy J. Ungar
Publikationsdatum
01.08.2011
Verlag
Springer International Publishing
Erschienen in
PharmacoEconomics / Ausgabe 8/2011
Print ISSN: 1170-7690
Elektronische ISSN: 1179-2027
DOI
https://doi.org/10.2165/11591570-000000000-00000

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