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Drugs
Erschienen in: Drugs 7/2012

01.05.2012 | Current Opinion

Coming to Terms with Nonsteroidal Anti-Inflammatory Drug Gastropathy

verfasst von: Dr Sanford H. Roth, MD

Erschienen in: Drugs | Ausgabe 7/2012

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Abstract

Despite well known complications, oral nonsteroidal anti-inflammatory drugs (NSAIDs) remain the most commonly prescribed medications in the US for musculoskeletal disorders such as osteoarthritis. Although there has been a recent focus on the cardiovascular and renal complications associated with these agents, NSAID gastropathy continues to be a particular concern in many patients, especially those at increased risk for serious adverse events, including the elderly. Complicating the diagnosis of NSAID gastropathy is its silent course, which, up to half of the time, is asymptomatic. Several strategies are currently employed by physicians to mitigate the risk of serious gastrointestinal events. These include either addition of a proton pump inhibitor to current nonselective NSAID therapy or the use of a cyclo-oxygenase-2—selective NSAID. Although these agents are effective at mitigating the overall risk of gastrointestinal adverse events, they fail to address NSAID-related cardiovascular and renal risks. Due to their reduced systemic absorption, topical NSAIDs may present a viable option for patients at increased risk for serious NSAID-related adverse events, including gastropathy.
Fußnoten
1
1 Roth and Bennett[3] were the first to distinguish ‘NSAID gastropathy’ from the global mid-century descriptor, ‘peptic ulcer disease’. The new nomenclature was directly inspired by a seminal literature report on unique NSAID-associated outcomes and host risk factors by Sun et al.[4]
 
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Metadaten
Titel
Coming to Terms with Nonsteroidal Anti-Inflammatory Drug Gastropathy
verfasst von
Dr Sanford H. Roth, MD
Publikationsdatum
01.05.2012
Verlag
Springer International Publishing
Erschienen in
Drugs / Ausgabe 7/2012
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI
https://doi.org/10.2165/11633740-000000000-00000

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