Pulmonary Scedosporium apiospermum Infection with Pulmonary Tumorlet in an Immunocompetent Patient

Nana Motokawa; Taiga Miyazaki; Atsuko Hara; Yuichi Fukuda; Shigeyuki Morino; Hiroaki Nakamura; Keisuke Iwasaki; Hiroshi Soda; Koichi Izumikawa; Katsunori Yanagihara; Hideaki Ohno; Yoshitsugu Miyazaki; Shigeru Kohno; Hiroshi Mukae

doi:10.2169/internalmedicine.1239-18

CASE REPORTS

Pulmonary Scedosporium apiospermum Infection with Pulmonary Tumorlet in an Immunocompetent Patient

Nana Motokawa, Taiga Miyazaki, Atsuko Hara, Yuichi Fukuda, Shigeyuki Morino, Hiroaki Nakamura, Keisuke Iwasaki, Hiroshi Soda, Koichi Izumikawa, Katsunori Yanagihara, Hideaki Ohno, Yoshitsugu Miyazaki, Shigeru Kohno, Hiroshi Mukae

Author information

Nana Motokawa
Division of Respiratory Medicine, Sasebo City General Hospital, Japan
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Taiga Miyazaki
Division of Respiratory Medicine, Sasebo City General Hospital, Japan
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Atsuko Hara
Division of Respiratory Medicine, Sasebo City General Hospital, Japan
Yuichi Fukuda
Division of Respiratory Medicine, Sasebo City General Hospital, Japan
Shigeyuki Morino
Division of Thoracic Surgery, Sasebo City General Hospital, Japan
Hiroaki Nakamura
Division of Thoracic Surgery, Sasebo City General Hospital, Japan
Keisuke Iwasaki
Division of Pathology, Sasebo City General Hospital, Japan
Hiroshi Soda
Division of Respiratory Medicine, Sasebo City General Hospital, Japan
Koichi Izumikawa
Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Japan
Katsunori Yanagihara
Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Hideaki Ohno
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Japan
Yoshitsugu Miyazaki
Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Japan
Shigeru Kohno
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Hiroshi Mukae
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: Scedosporium apiospermum, Pseudallescheria boydii, pulmonary tumorlet, fungus ball

JOURNAL OPEN ACCESS

2018 Volume 57 Issue 23 Pages 3485-3490

DOI https://doi.org/10.2169/internalmedicine.1239-18

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Abstract

Scedosporium apiospermum is an opportunistic fungus that can cause various types of infections, including localized infections and life-threatening disseminated infections, particularly in immunocompromised patients. Treatment is especially challenging due to its multidrug resistance. We herein report the case of a 73-year-old woman who was non-immunocompromised but developed S. apiospermum lung infection and a pulmonary tumorlet. To our knowledge, this is the first report of the coexistence of pulmonary S. apiospermum infection and tumorlet. The lung lesion was successfully treated by surgical excision without any antifungal agents, and no recurrence of the tumorlet or S. apiospermum infection has occurred.

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