Acute-onset Autoimmune Hepatitis Treated with Living Donor-liver Transplantation

Keiko KAWAI; Kojiro MICHITAKA; Shozo MIYAUCHI; Masahiro SANO; Masanori ABE; Tsuneyuki NINOMIYA; Bunzo MATSUURA; Toshikazu MASUMOTO; Fazle AKBAR; Norio HORIIKE; Morikazu ONJI

doi:10.2169/internalmedicine.42.158

Keiko KAWAI, Kojiro MICHITAKA, Shozo MIYAUCHI, Masahiro SANO, Masanori ABE, Tsuneyuki NINOMIYA, Bunzo MATSUURA, Toshikazu MASUMOTO, Fazle AKBAR, Norio HORIIKE, Morikazu ONJI

Author information

Keiko KAWAI
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Kojiro MICHITAKA
The Endoscopy Center, Ehime University School of Medicine, Onsen-gun
Shozo MIYAUCHI
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Masahiro SANO
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Masanori ABE
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Tsuneyuki NINOMIYA
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Bunzo MATSUURA
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Toshikazu MASUMOTO
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Fazle AKBAR
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Norio HORIIKE
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun
Morikazu ONJI
The Third Department of Internal Medicine, Ehime University School of Medicine, Onsen-gun

Keywords: rejection, recurrence, severe

JOURNAL FREE ACCESS

2003 Volume 42 Issue 2 Pages 158-162

DOI https://doi.org/10.2169/internalmedicine.42.158

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Abstract

A 50-year-old woman was diagnosed with acute-onset autoimmune hepatitis. She did not respond to steroid therapy including pulse therapy, and was subsequently treated with living donor-liver transplantation 36 days after the beginning of steroid therapy. Except for a period of transient mild acute rejection, her liver function tests remained within a normal range for 2.5 years after the operation. The courses of autoimmune hepatitis patients treated with living-donor liver transplantation have not been previously documented to our knowledge. Living donor-liver transplantation is thought to be one of the therapy options for severe autoimmune hepatitis.
(Internal Medicine 42: 158-162, 2003)

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