Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Bridging Use of Plasma Exchange and Continuous Hemodiafiltration before Living Donor Liver Transplantation in Fulminant Wilson's Disease
Yoshiko NAGATA, Hirofumi UTO, Satoru HASUIKE, Akio IDO, Katsuhiro HAYASHI, Toshiharu ETO, Toshiro HAMAKAWA, Koichi TANAKA, Hirohito TSUBOUCHI
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Keywords: Wilson's disease, hepatic failure, hemolytic anemia, plasma exchange, hemodiafiltration
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2003 Volume 42 Issue 10 Pages 967-970

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Abstract

A 15-year-old girl presented with acute hepatic failure showing ascites and hepatic encephalopathy, accompanied by hemolytic anemia. She was diagnosed as having fulminant Wilson's disease (FWD). Plasma exchange (PE), continuous hemodiafiltration (CHDF) and D-penicillamine administration were started immediately. Copper [24, 000 μg] was removed by PE and CHDF over three days, which relieved the jaundice and the consciousness disorder. A successful liver transplant followed. FWD progresses rapidly and often liver transplantation is the only possible therapy. In this case, PE and CHDF were an effective therapy bridge until liver transplantation.
(Internal Medicine 42: 967-970, 2003)

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