Relationship between Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle

Toshiyuki Nagasawa; Mitsuhiko Noda; Sayaka Katagiri; Maki Takaichi; Yoshihiko Takahashi; Nawarat Wara-Aswapati; Hiroaki Kobayashi; Satoko Ohara; Yoko Kawaguchi; Tadashi Tagami; Yasushi Furuichi; Yuichi Izumi

doi:10.2169/internalmedicine.49.3351

REVIEW ARTICLE

Relationship between Periodontitis and Diabetes - Importance of a Clinical Study to Prove the Vicious Cycle

Toshiyuki Nagasawa, Mitsuhiko Noda, Sayaka Katagiri, Maki Takaichi, Yoshihiko Takahashi, Nawarat Wara-Aswapati, Hiroaki Kobayashi, Satoko Ohara, Yoko Kawaguchi, Tadashi Tagami, Yasushi Furuichi, Yuichi Izumi

Author information

Toshiyuki Nagasawa
Division of Periodontology and Endodontology, School of Dentistry, Health Science University of Hokkaido
Mitsuhiko Noda
Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine
Sayaka Katagiri
Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
Maki Takaichi
Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine
Yoshihiko Takahashi
Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine
Nawarat Wara-Aswapati
Department of Periodontology, Faculty of Dentistry, Khon Kaen University
Hiroaki Kobayashi
Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
Satoko Ohara
Oral Diagnosis and General Dentistry, Dental Hospital, Faculty of Dentistry, Tokyo Medical and Dental University
Yoko Kawaguchi
Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University
Tadashi Tagami
Department of Dentistry and Oral Surgery, National Center for Global Health and Medicine
Yasushi Furuichi
Division of Periodontology and Endodontology, School of Dentistry, Health Science University of Hokkaido
Yuichi Izumi
Section of Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University
Global Center for Excellence for Tooth and Bone Research, Tokyo Medical and Dental University

Keywords: periodontitis, diabetes

JOURNAL OPEN ACCESS

2010 Volume 49 Issue 10 Pages 881-885

DOI https://doi.org/10.2169/internalmedicine.49.3351

Details

Abstract

Periodontitis is regarded to have a close relationship to diabetes mellitus. In Japan, some cohort studies have indicated that there is a significant positive association of obesity plus metabolic syndrome with periodontal diseases. As such, an increasing number of studies suggest a relationship between periodontitis and diabetes, most of which are epidemiologic association. In this review, we have summarized the possible evidence of a relationship between periodontitis and diabetes. To date, little evidence has been reported to indicate that diabetes and/or glucose intolerance has in fact had a significant cause-effect relationship with periodontal disease. In this regard, it is important to directly uncover the relation, i.e., to prove the effect of therapeutic approaches to periodontitis upon mitigation of glycemic control in diabetic patients, which would be a direct evidence of its causal nature. Therefore a study should be undertaken to this effect.

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