Successful Treatment of Histiocytic Sarcoma and Concurrent HIV Infection Using a Combination of CHOP and Antiretroviral Therapy

Kosuke Narita; Rintaro Noro; Masahiro Seike; Masaru Matsumoto; Kazue Fujita; Jiro Matsumura; Mikiko Takahashi; Masashi Kawamoto; Akihiko Gemma

doi:10.2169/internalmedicine.52.0523

CASE REPORTS

Successful Treatment of Histiocytic Sarcoma and Concurrent HIV Infection Using a Combination of CHOP and Antiretroviral Therapy

Kosuke Narita, Rintaro Noro, Masahiro Seike, Masaru Matsumoto, Kazue Fujita, Jiro Matsumura, Mikiko Takahashi, Masashi Kawamoto, Akihiko Gemma

Author information

Kosuke Narita
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Rintaro Noro
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Masahiro Seike
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Masaru Matsumoto
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Kazue Fujita
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan
Jiro Matsumura
Department of Microbiology and Immunology, Nippon Medical School, Japan
Mikiko Takahashi
Department of Analytic Human Pathology, Nippon Medical School, Japan
Masashi Kawamoto
Department of Clinical Pathology, University Hospital, Mizonokuchi, Teikyo University School of Medicine, Japan
Akihiko Gemma
Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Japan

Keywords: histiocytic sarcoma, CHOP, human immunodeficiency virus-1 (HIV), antiretroviral therapy (ART)

JOURNAL OPEN ACCESS

2013 Volume 52 Issue 24 Pages 2805-2809

DOI https://doi.org/10.2169/internalmedicine.52.0523

Details

Abstract

Histiocytic sarcoma (HS) is a rare malignancy of soft tissues with an unknown etiology. The CHOP (cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride and prednisolone) regimen is often adopted as first-line chemotherapy; however, its therapeutic efficacy against HS is usually low. We herein first present the case of a patient with HS who was infected with human immunodeficiency virus-1 (HIV) in whom treatment with a combination of CHOP and antiretroviral therapy (ART) was successful. The patient has been in complete remission for 12 months following the discontinuation of chemotherapy under continuous ART. This case report may help to promote further investigation of both HS and HIV-related malignancy.

Corresponding author

Register with J-STAGE for free!