Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review

Yoshiyuki Murawaki; Kazuo Yashima; Satoshi Horie; Masahiko Miura; Jun Kato; Takayuki Hirai; Kazuki Takeda; Michimori Kono; Manabu Yoshida; Hajime Isomoto

doi:10.2169/internalmedicine.0246-22

CASE REPORTS

Helicobacter pylori-negative Gastric Adenocarcinoma Mimicking Verrucous Gastritis in the Antrum: A Case Report and Literature Review

Yoshiyuki Murawaki, Kazuo Yashima, Satoshi Horie, Masahiko Miura, Jun Kato, Takayuki Hirai, Kazuki Takeda, Michimori Kono, Manabu Yoshida, Hajime Isomoto

Author information

Yoshiyuki Murawaki
Department of Gastroenterology, Matsue City Hospital, Japan
Kazuo Yashima
Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Japan
Satoshi Horie
Department of Gastroenterology, Matsue City Hospital, Japan
Masahiko Miura
Department of Gastroenterology, Matsue City Hospital, Japan
Jun Kato
Department of Gastroenterology, Matsue City Hospital, Japan
Takayuki Hirai
Department of Gastroenterology, Matsue City Hospital, Japan
Kazuki Takeda
Department of Gastroenterology, Matsue City Hospital, Japan
Michimori Kono
Department of Gastroenterology, Matsue City Hospital, Japan
Manabu Yoshida
Department of Pathology, Matsue City Hospital, Japan
Hajime Isomoto
Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Japan

Keywords: Helicobacter pylori-negative, gastrointestinal phenotype, differentiated gastric adenocarcinoma

JOURNAL OPEN ACCESS

2023 Volume 62 Issue 14 Pages 2063-2069

DOI https://doi.org/10.2169/internalmedicine.0246-22

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Abstract

A 46-year-old man was referred to our hospital for the examination of a flat elevated lesion with an erosion-like depression, located on the greater curvature of the antrum. Endoscopic submucosal dissection was performed. Histological findings of the resected specimen demonstrated a well-differentiated tubular adenocarcinoma with a diameter of 12 mm. No atrophy was observed in the tumor-adjacent mucosa. Serum Helicobacter pylori antibody estimation and ¹³C-urea breath tests yielded negative results. Immunohistochemical staining was positive for both gastric mucin and intestinal mucin. The final diagnosis was well-differentiated tubular adenocarcinoma with a gastrointestinal phenotype that originated in mucosa uninfected by H. pylori.

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