A Rare Case of Idiopathic Hypoparathyroidism with Varied Neurological Manifestations

Seijirou ABE; Katsuyoshi TOJO; Kimiyoshi ICHIDA; Takashi SHIGEMATSU; Takashi HASEGAWA; Masayo MORITA; Osamu SAKAI

doi:10.2169/internalmedicine.35.129

Seijirou ABE, Katsuyoshi TOJO, Kimiyoshi ICHIDA, Takashi SHIGEMATSU, Takashi HASEGAWA, Masayo MORITA, Osamu SAKAI

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Keywords: hypocalcemia, basal ganglia calcification, basal ganglia disease, parkinsonism, dysarthria

JOURNAL FREE ACCESS

1996 Volume 35 Issue 2 Pages 129-134

DOI https://doi.org/10.2169/internalmedicine.35.129

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Abstract

A 47-year-old man was admitted for evaluation of unsteady gait, postural instability, and dysarthria. On admission, neurological examinations revealed cerebellar ataxia, extrapyramidal signs including parkinsonism and positive Trousseau's sign. Laboratory findings revealed severe hypocalcemia and hyperphosphatemia, and serum intact parathyroid hormone was not detectable. Brain computed tomography revealed severe calcification of basal ganglia and dentate nuclei. He was diagnosed as idiopathic hypoparathyroidism; treatment with 1α (OH) vitamin D₃ brought marked improvement of neurological manifestations. We report a rare case of idiopathic hypoparathyroidism presenting with extrapyramidal and cerebellar dysfunction with a review of literature.
(Internal Medicine 35: 129-134, 1996)

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