Myelodysplastic Syndrome Accompanied by Addison's Disease and Multiple Autoimmune Phenomena: Steroid Therapy Resolved Cytopenias and All Immune Disorders

Kotaro FUNATO; Yuzuru KURIYAMA; Yoshiko UCHIDA; Akitaka SUZUKI; Keisuke MIYAZAWA; Kazuma OHYASHIKI

doi:10.2169/internalmedicine.40.1041

Kotaro FUNATO, Yuzuru KURIYAMA, Yoshiko UCHIDA, Akitaka SUZUKI, Keisuke MIYAZAWA, Kazuma OHYASHIKI

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Keywords: autoimmune disease, rheumatoid arthritis, autoimmune hemolytic anemia, autoimmune thrombocytopenic purpura

JOURNAL FREE ACCESS

2001 Volume 40 Issue 10 Pages 1041-1044

DOI https://doi.org/10.2169/internalmedicine.40.1041

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Abstract

We report here a patient with myelodysplastic syndromes (MDS), which was complicated with several autoimmune disorders and asymptomatic immunologic abnormalities. An 82-year-old woman with refractory anemia (RA) rapidly developed thrombocytopenia with the appearance of symptoms such as purpura, fatigue, anorexia, and weight loss. Furthermore, clinical examinations revealed that she also had Addison's disease, rheumatoid arthritis, and autoimmune hematological diseases such as thrombocytopenia and hemolytic anemia. However, the cytopenia and all autoimmune disorders were remarkably improved after she received steroid therapy.
(Internal Medicine 40: 1041-1044, 2001)

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