Myelodysplasia Associated with Acquired Immunodeficiency Syndrome

Tomiko RYU; Masaki IKEDA; Yuko OKAZAKI; Hitoshi TOKUDA; Naoto YOSHINO; Mitsuo HONDA; Satoshi KIMURA; Yasusada MIURA

doi:10.2169/internalmedicine.40.795

Tomiko RYU, Masaki IKEDA, Yuko OKAZAKI, Hitoshi TOKUDA, Naoto YOSHINO, Mitsuo HONDA, Satoshi KIMURA, Yasusada MIURA

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Keywords: human immunodeficiency virus (HIV) infection, pancytopenia, myelodysplastic syndrome, HIV-myelopathy, hematopoietic progenitor cells

JOURNAL FREE ACCESS

2001 Volume 40 Issue 8 Pages 795-801

DOI https://doi.org/10.2169/internalmedicine.40.795

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Abstract

Two cases of acquired immunodeficiency syndrome with myelodysplasia are presented. Case 1 was admitted because of Pneumocystis carinii pneumonia. Mild anemia, thrombocytopenia and hypersegmented neutrophils were observed. After the administration of trimethoprim-sulfamethoxazole and antiretroviral therapy, pancytopenia progressed. Bone marrow (BM) showed dysplastic hematopoiesis, suggesting human immunodeficiency virus-myelopathy. Case 2 was hospitalized due to progressive multifocal leukoencephalopathy. BM specimen obtained for thrombocytopenia showed myelodysplasia similar to myelodysplastic syndrome, suggesting that HIV may have an influence on hematopoietic progenitor cells.
(Internal Medicine 40: 795-801, 2001)

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