Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Cushing's Syndrome with a Large Pituitary Adenoma Producing both Corticotropin-releasing Hormone (CRH) and Adrenocorticotropin (ACTH)
Yuya YAMADA, Akiko OHASHI, Toru INOUE, Katsuhiko SAKAGUCHI, Takahiro TSUJIMURA, Daisuke OKAMOTO, Hiroaki ITATANI, Naomi FUJIMOTO, Kazumasa KUSAKA, Hisako FUSHIMI
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Keywords: cortisol, dexamethasone suppression test, ectopic hormone-producing tumor
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2002 Volume 41 Issue 7 Pages 549-554

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Abstract

A 57-year-old man showed high serum cortisol, plasma adrenocorticotropin (ACTH) and corticotropin-releasing hormone (CRH) levels with a large pituitary tumor and a prostatic cancer. High dose dexamethasone did not suppress cortisol secretion and CRH administration did not stimulate cortisol secretion. After surgical removal of the pituitary tumor, plasma CRH, ACTH and serum cortisol levels were normalized. Histological examinations showed pituitary adenoma and prostatic adenocarcinoma, and pituitary adenoma was stained with both anti-CRH and anti-ACTH antibodies, but prostatic cancer was not stained. A CRH-producing pituitary adenoma is a new type of Cushing's syndrome.
(Internal Medicine 41: 549-554, 2002)

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