Renal Transplant Recipient with Chronic Hepatitis C Who Obtained Sustained Viral Response after Interferon-β Therapy

Ichiro KONISHI; Norio HORIIKE; Kojiro MICHITAKA; Nobuko OCHI; Shinya FURUKAWA; Hisaka MINAMI; Morikazu ONJI

doi:10.2169/internalmedicine.43.931

Gastrointestinal Diseases

Renal Transplant Recipient with Chronic Hepatitis C Who Obtained Sustained Viral Response after Interferon-β Therapy

Ichiro KONISHI, Norio HORIIKE, Kojiro MICHITAKA, Nobuko OCHI, Shinya FURUKAWA, Hisaka MINAMI, Morikazu ONJI

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Keywords: IFN-β, renal transplant recipient, chronic hepatitis C, sustained viral response

JOURNAL OPEN ACCESS

2004 Volume 43 Issue 10 Pages 931-934

DOI https://doi.org/10.2169/internalmedicine.43.931

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Abstract

A 44-year-old Japanese woman with a history of living-related renal transplantation was treated with interferon-β (IFN-β) for chronic infection with sero-group 2 hepatitis C virus (HCV). Serum HCV-RNA titer was 160 kilo-international units/ml. Treatment with intravenous IFN-β daily was given for 6 weeks. Serum HCV-RNA was undetectable at 3 weeks after initiating therapy. Renal graft rejection did not occur. Six months after completing therapy, she obtained sustained viral response. This case demonstrates that IFN-β therapy safely induced clearance of HCV in a renal transplant recipient with stable renal function, low viral load and/or HCV sero-group 2.

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