Radiological and Pathological Correlation of Lung Malignant Tumors Treated with Percutaneous Radiofrequency Ablation

Osamu HATAJI; Koichiro YAMAKADO; Atsuhiro NAKATSUKA; Shuichi MURASHIMA; Hajime FUJIMOTO; Yoichi NISHII; Hiroki NAKAHARA; Hiroyasu KOBAYASHI; Esteban C GABAZZA; Osamu TAGUCHI

doi:10.2169/internalmedicine.44.865

CASE REPORTS

Radiological and Pathological Correlation of Lung Malignant Tumors Treated with Percutaneous Radiofrequency Ablation

Osamu HATAJI, Koichiro YAMAKADO, Atsuhiro NAKATSUKA, Shuichi MURASHIMA, Hajime FUJIMOTO, Yoichi NISHII, Hiroki NAKAHARA, Hiroyasu KOBAYASHI, Esteban C GABAZZA, Osamu TAGUCHI

Author information

Osamu HATAJI
Department of Internal Medicine, Matsuzaka Municipal Hospital, Mie
Koichiro YAMAKADO
Department of Radiology, Mie University Hospital
Atsuhiro NAKATSUKA
Department of Radiology, Mie University Hospital
Shuichi MURASHIMA
Department of Radiology, Mie University Hospital
Hajime FUJIMOTO
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mie University Hospital
Yoichi NISHII
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mie University Hospital
Hiroki NAKAHARA
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mie University Hospital
Hiroyasu KOBAYASHI
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mie University Hospital
Esteban C GABAZZA
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mie University Hospital
Osamu TAGUCHI
Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Mie University Hospital

Keywords: radiofrequency ablation, lung tumor, radiological features, pathological findings

JOURNAL OPEN ACCESS

2005 Volume 44 Issue 8 Pages 865-869

DOI https://doi.org/10.2169/internalmedicine.44.865

Details

Abstract

Radiological and histological correlation was evaluated in patients with malignant tumors of the lung that underwent radiofrequency ablation (RFA). One of the patients had a primary lung tumor and another patient had three metastatic lung tumors. RFA was performed under computed tomography (CT) fluoroscopic guidance. CT showed ground glass shadows around the tumoral lesions immediately after RFA, but one week later homogenous opacification without tumoral enhancement was noted. Two months after RFA, most lesions showed cystic changes without activity on FDG-PET. Histological evaluation showed massive coagulation necrosis throughout the tumor and some viable cells at the peripheral areas in all lesions. Although RFA is a promising therapeutic approach for malignant lung tumors, some viable cells may persist in peripheral areas of the tumor.

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